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Effects of Oxytocin on the Isolated Vas Deferens of the Rat

Overview
Journal Br J Pharmacol
Publisher Wiley
Specialty Pharmacology
Date 1980 Jul 1
PMID 7397448
Citations 3
Authors
J V Beneit
A Hidalgo
J L Tamargo
Affiliations
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Abstract

1 The effect of oxytocin was studied on the isolated vas deferens of the rat. 2 Oxytocin (25 to 200 mu/ml) reversibly reduced the contractile response induced by noradrenaline, dopamine and acetylcholine. 3 Oxytocin (400 mu/ml) abolished the response to potassium. 4 The contractions evoked in the vas deferens by field stimulation were also reduced by oxytocin (50 to 200 mg/ml). The inhibitory effect of the drug was related to the external calcium concentration. 5 It is suggested that oxytocin depresses the contractile responses in the vas deferens at least partly by reducing the availability of calcium from an extracellular source.

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Stadler B, Whittaker M, Exintaris B, Middendorff R Front Endocrinol (Lausanne). 2020; 11:565731.

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Oxytocin-induced contractions within rat and rabbit ejaculatory tissues are mediated by vasopressin V1A receptors and not oxytocin receptors.

Gupta J, Russell R, Wayman C, Hurley D, Jackson V Br J Pharmacol. 2008; 155(1):118-26.

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References
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