Excitatory and Inhibitory Effects of Serotonin on Sensorimotor Reactivity Measured with Acoustic Startle

Overview

Journal Science

Specialty Science

Date 1980 Jul 25

PMID 7394520

Citations 32

Authors

M Davis

D I Strachan

E Kass

Affiliations

Soon will be listed here.

Abstract

Serotonin infused into the lateral ventricle in rats produced a dose-dependent depression of the acoustic startle reflex. When infused onto the spinal cord, serotonin produced a dose-dependent increase in startle. Thus the same neurotransmitter can modulate the same behavior in opposite ways, depending on which part of the central nervous system is involved.

Citing Articles

Serotonergic modulation of local network processing in V1 mirrors previously reported signatures of local network modulation by spatial attention.

Patel A, Kawaguchi K, Seillier L, Nienborg H Eur J Neurosci. 2023; 57(8):1368-1382.

PMID: 36878879 PMC: 11610500. DOI: 10.1111/ejn.15953.

Differential Serotonergic Modulation of Synaptic Inputs to the Olfactory Cortex.

Piszar I, Lorincz M Int J Mol Sci. 2023; 24(3).

PMID: 36768274 PMC: 9916768. DOI: 10.3390/ijms24031950.

Sex-Specific Role for Dopamine Receptor D2 in Dorsal Raphe Serotonergic Neuron Modulation of Defensive Acoustic Startle and Dominance Behavior.

Lyon K, Rood B, Wu L, Senft R, Goodrich L, Dymecki S eNeuro. 2020; 7(6).

PMID: 33214315 PMC: 7768286. DOI: 10.1523/ENEURO.0202-20.2020.

Mechanisms underlying gain modulation in the cortex.

Ferguson K, Cardin J Nat Rev Neurosci. 2020; 21(2):80-92.

PMID: 31911627 PMC: 7408409. DOI: 10.1038/s41583-019-0253-y.

Serotonergic Modulation of Walking in Drosophila.

Howard C, Chen C, Tabachnik T, Hormigo R, Ramdya P, Mann R Curr Biol. 2019; 29(24):4218-4230.e8.

PMID: 31786064 PMC: 6935052. DOI: 10.1016/j.cub.2019.10.042.