Optogenetic Activation of Dorsal Raphe Serotonin Neurons Rapidly Inhibits Spontaneous But Not Odor-Evoked Activity in Olfactory Cortex

Overview

Journal J Neurosci

Specialty Neurology

Date 2016 Jan 8

PMID 26740645

Citations 41

Authors

Eran Lottem

Magor L Lorincz

Zachary F Mainen

Affiliations

Soon will be listed here.

Abstract

Significance Statement: Serotonin is implicated in a wide variety of (pato)physiological functions including perception, but its precise role has remained elusive. Here, using optogenetic tools in vivo, we show that serotonergic neuromodulation prominently inhibits the spontaneous electrical activity of neurons in the primary olfactory cortex on a rapid (<1 s) timescale but leaves sensory responses unaffected. These results identify a new role for serotonergic modulation in rapidly changing the balance between different sources of neural activity in sensory systems.

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