Fc Receptors on Lymphocytes from the Blood of Rheumatoid Arthritis Patients and Normal Controls: a Comparison of Four Fc Receptor Assays

Overview

Journal Clin Exp Immunol

Publisher Oxford University Press

Specialty Allergy & Immunology

Date 1981 Sep 1

PMID 7337961

Citations 3

Authors

R K Sharpin

J D Wilson

Affiliations

Soon will be listed here.

Abstract

Peripheral blood lymphocytes (PBL) from rheumatoid arthritis (RA) patients and healthy controls (NC) were assayed for Fc receptors by four methods. Three of the four assays showed RA PBL to contain a greater proportion and number of Fc receptor-bearing cells than PBL from healthy controls. This confirmed our earlier report and indicated that the proportion of Fc receptor-bearing cells detected can be influenced by the test system. Neither the proportion of B, nor the non-B, non-T lymphocytes was consistently increased in RA PBL, suggesting that the increase found results from an increase in Fc gamma receptor-positive T cells.

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Lymphocytes bearing Fc gamma receptors in rheumatoid arthritis. II. Phenotypic characterisation of mononuclear cells forming Facb rosettes in RA.

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References

Bach J, Delrieu F, Delbarre F . The rheumatoid rosette. A diagnostic test unifying seropositive and seronegative rheumatoid arthritis. Am J Med. 1970; 49(2):213-22. DOI: 10.1016/s0002-9343(70)80077-8. View

Sharpin R, Simmons M, Wilson J . TG cells in peripheral blood lymphocytes from patients with rheumatoid arthritis. Clin Exp Immunol. 1981; 45(3):538-43. PMC: 1537421. View

Froland S, Wisloff F, Michaelsen T . Human lymphocytes with receptors for IgG. A population of cells distinct from T- and B-lymphocytes. Int Arch Allergy Appl Immunol. 1974; 47(1):124-38. DOI: 10.1159/000231207. View

Horwitz D, Lobo P . Characterizaiton of two populations of human lymphocytes bearing easily detectable surface immunoglobulin. J Clin Invest. 1975; 56(6):1464-72. PMC: 333124. DOI: 10.1172/JCI108227. View

Ferrarini M, Moretta L, Abrile R, Durante M . Receptors for IgG molecules on human lymphocytes forming spontaneous rosettes with sheep red cells. Eur J Immunol. 1975; 5(1):70-2. DOI: 10.1002/eji.1830050115. View

Gergely P, Bakacs T, Cornain S, Klein E . Fc receptors on human blood B lymphocytes. Clin Exp Immunol. 1977; 28(1):99-102. PMC: 1540869. View

Sharpin R, Wilson J . Studies on the nature of EA binding by lymphocytes from rheumatoid arthritis patients. Clin Exp Immunol. 1977; 29(2):213-9. PMC: 1541086. View

Winfield J, Lobo P, Hamilton M . Fc receptor heterogeneity: immunofluorescent studies of B, T, and "third population" lymphocytes in human blood with rabbit IgG b4/anti-b4 complexes. J Immunol. 1977; 119(5):1778-84. View

Horwitz D . Human blood L lymphocytes in patients with active systemic lupus erythematosus, rheumatoid arthritis and scleroderma: a comparison with T and B cells. Clin Exp Immunol. 1977; 30(3):370-8. PMC: 1541144. View

10.

Burmester G, Kalden J, Peter H, Schedel I, Beck P, Wittenborg A . Immunological and functional characteristics of peripheral blood and synovial fluid lymphocytes from patients with rheumatoid arthritis. Scand J Immunol. 1978; 7(5):405-17. DOI: 10.1111/j.1365-3083.1978.tb00471.x. View

11.

Sany J, Clot J, Andary M, PARADIS B, Serre H . [Fc-gamma-receptor cells and rheumatoid arthritis]. Rev Rhum Mal Osteoartic. 1978; 45(5):305-10. View

12.

Wooley P, Panayi G . Studies of lymphocytes in rheumatoid arthritis. I. Uptake of 125I-heat aggregated human IgG by Fc-receptor bearing lymphocytes. Ann Rheum Dis. 1978; 37(4):343-6. PMC: 1000241. DOI: 10.1136/ard.37.4.343. View

13.

Pang G, Wilson J . Different rosette assays for detecting Fc receptor-bearing lymphocytes measure different subpopulations. Immunology. 1978; 35(2):407-14. PMC: 1457243. View

14.

Biberfeld G, Nilsson E, Biberfeld P . T lymphocyte subpopulations in synovial fluid of patients with rheumatic disease. Arthritis Rheum. 1979; 22(9):978-82. DOI: 10.1002/art.1780220905. View

15.

Froebel K, Sturrock R, Reynolds P, Grennan A, Roxburgh A, MacSween R . In-vitro reactions of lymphocytes in rheumatoid arthritis and other rheumatic diseases. Ann Rheum Dis. 1979; 38(6):535-43. PMC: 1000415. DOI: 10.1136/ard.38.6.535. View

16.

HALLBERG T, GURNER B, Coombs R . Opsonic adherence of sensitized ox red cells to human lymphocytes as measured by rosette formation. Int Arch Allergy Appl Immunol. 1973; 44(4):500-13. DOI: 10.1159/000230956. View