Lymphocytes Bearing Fc Gamma Receptors in Rheumatoid Arthritis. II. Phenotypic Characterisation of Mononuclear Cells Forming Facb Rosettes in RA

Overview

Journal Ann Rheum Dis

Specialty Rheumatology

Date 1985 Jan 1

PMID 3155932

Citations 4

Authors

V R Winrow

L J Eales

N D Hall

N J Goulding

I M Hunneyball

Affiliations

Soon will be listed here.

Abstract

We have previously reported an increased proportion of Facb-rosette forming cells in the peripheral blood of patients with rheumatoid arthritis in comparison with healthy controls. The present study investigates the surface phenotype of these cells by means of monoclonal antibodies and a variety of rosetting and lymphocyte fractionation techniques. Facb-R+ cells were found to lack surface markers characteristic of T and B lymphocytes. Studies with monoclonal reagents showed a positive reaction with OKIa1, OKM1, and another monocyte-specific antibody. Fac-R+ cells were recognised by anti-HLA-DR reagents but did not bind the monoclonal antibody 17.15 that recognises a determinant on HLA-DR antigens expressed by lymphocytes but not monocytes. These results show that Facb-R+ cells share certain surface characteristics with monocytes, though they are not phagocytic. These observations are consistent with an accessory role for Facb-R+ cells in the immune response.

Citing Articles

Expanded Fc receptor bearing 'third population' lymphocytes in rheumatoid arthritis: analysis by cell partitioning in two-polymer aqueous phase systems.

Michalski J, Zanki S, Walter H Ann Rheum Dis. 1988; 47(10):878-9.

PMID: 3196086 PMC: 1003622. DOI: 10.1136/ard.47.10.878.

Lymphocytes bearing Fc gamma receptors in rheumatoid arthritis. III. Immunoregulatory function associated with Facb rosette-forming cells.

Eales L, Goulding N, Hall N, Winrow V, Hunneyball I Ann Rheum Dis. 1985; 44(1):8-12.

PMID: 3155933 PMC: 1001559. DOI: 10.1136/ard.44.1.8.

Lymphocytes bearing Fc gamma receptors in rheumatoid arthritis. IV. Increased numbers and activation of Facb-R+ cells after immunisation of healthy individuals.

Goulding N, Eales L, Hall N Ann Rheum Dis. 1986; 45(11):925-31.

PMID: 3098196 PMC: 1002021. DOI: 10.1136/ard.45.11.925.

Feedback regulation of antibody production: a role in rheumatoid arthritis?.

Kalsi J, Hall N Ann Rheum Dis. 1991; 50(11):833-5.

PMID: 1772303 PMC: 1004571. DOI: 10.1136/ard.50.11.833.

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