VP-16-213. A Phase II Trial Using a Weekly Schedule

Forty-six patients with various malignancies refractory to standard chemotherapy were treated with VP-16-213 using a weekly schedule. Only one patient responded to this regimen. perivenous infiltration of VP-16-213 resulted in a soft-tissue ulceration; this side effect has not been reported before. We conclude that VP-16-213 is of little utility when used in a weekly fashion in previously treated patients.