Increased Muscle Calcium. A Possible Cause of Mitochondrial Dysfunction and Cellular Necrosis in Denervated Rat Skeletal Muscle

Overview

Journal Biochem J

Specialty Biochemistry

Date 1981 Jun 15

PMID 7317007

Citations 8

Authors

M Joffe

N Savage

H Isaacs

Affiliations

Soon will be listed here.

Abstract

Mitochondrial preparations derived from denervated rat skeletal muscle and paired controls were characterized with respect to their ability to take up externally added Ca2+. The denervated and control muscle homogenates and mitochondrial [Ca2+] were also determined. Our data indicate that the denervated mitochondria are able to take up less Ca2+ than the controls before uncoupling occurs. This defect is associated with elevated [Ca2+] in homogenate and mitochondrial fractions in the denervated state. The causal relationship between Ca2+ overload, mitochondrial functional damage and cell necrosis is discussed.

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References

Wrogemann K, BLANCHAER M, Jacobson B . A calcium-associated magnesium-responsive defect of respiration and oxidative phosphorylation by skeletal muscle mitochondria of BIO 14.6 dystrophic hamsters. Life Sci II. 1970; 9(20):1167-73. DOI: 10.1016/0024-3205(70)90035-4. View

Chance B . THE ENERGY-LINKED REACTION OF CALCIUM WITH MITOCHONDRIA. J Biol Chem. 1965; 240:2729-48. View

Gear A, Albert A, Bednarek J . The effect of the hypocholesterolemic drug clofibrate on liver mitochondrial biogenesis. A role for neutral mitochondrial proteases. J Biol Chem. 1974; 249(20):6495-504. View

Mezon B, Wrogemann K, BLANCHAER M . Differing populations of mitochondria isolated from the skeletal muscle of normal and dystrophic hamsters. Can J Biochem. 1974; 52(11):1024-32. DOI: 10.1139/o74-143. View

SCHOTLAND D, DiMauro S, Bonilla E, Scarpa A, Lee C . Neuromuscular disorder associated with a defect in mitochondrial energy supply. Arch Neurol. 1976; 33(7):475-9. DOI: 10.1001/archneur.1976.00500070017003. View

Bradford M . A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem. 1976; 72:248-54. DOI: 10.1016/0003-2697(76)90527-3. View

Ringel S, Bender A, Engel W . Extrajunctional acetylcholine receptors. Alterations in human and experimental neuromuscular diseases. Arch Neurol. 1976; 33(11):751-8. DOI: 10.1001/archneur.1976.00500110019004. View

KAR N, Pearson C . A calcium-activated neutral protease in normal and dystrophic human muscle. Clin Chim Acta. 1976; 73(2):293-7. DOI: 10.1016/0009-8981(76)90175-3. View

Cullen M, Pluskal M . Early changes in the ultrastructure of denervated rat skeletal muscle. Exp Neurol. 1977; 56(1):115-31. DOI: 10.1016/0014-4886(77)90143-1. View

10.

Wrogemann K, Pena S . Mitochondrial calcium overload: A general mechanism for cell-necrosis in muscle diseases. Lancet. 1976; 1(7961):672-4. DOI: 10.1016/s0140-6736(76)92781-1. View

11.

Publicover S, Duncan C, Smith J . The use of A23187 to demonstrate the role of intracellular calcium in causing ultrastructural damage in mammalian muscle. J Neuropathol Exp Neurol. 1978; 37(5):554-7. View

12.

Haas R, Heinrich P . The localization of an intracellular membrane-bound proteinase from rat liver. Eur J Biochem. 1978; 91(1):171-8. DOI: 10.1111/j.1432-1033.1978.tb20949.x. View

13.

Duncan C . Role of intracellular calcium in promoting muscle damage: a strategy for controlling the dystrophic condition. Experientia. 1978; 34(12):1531-5. DOI: 10.1007/BF02034655. View

14.

Haas R, Heinrich P . Cleavage specificity of the serine proteinase from rat liver mitochondria. Biochem Biophys Res Commun. 1978; 85(3):1039-46. DOI: 10.1016/0006-291x(78)90647-2. View

15.

Neerunjun J, Dubowitz V . Increased calcium-activated neutral protease activity in muscles of dystrophic hamsters and mice. J Neurol Sci. 1979; 40(2-3):105-11. DOI: 10.1016/0022-510x(79)90196-5. View

16.

Haas R, Heinrich P . A novel SH-type carboxypeptidase in the inner membrane of rat-liver mitochondria. Eur J Biochem. 1979; 96(1):9-15. DOI: 10.1111/j.1432-1033.1979.tb13007.x. View

17.

Crompton M, Carafoli E . The measurement of Ca2+ movements in mitochondria. Methods Enzymol. 1979; 56:338-52. DOI: 10.1016/0076-6879(79)56031-5. View

18.

JASMIN G, SOLYMOSS B, Proschek L . Therapeutic trials in hamster dystrophy. Ann N Y Acad Sci. 1979; 317:338-48. DOI: 10.1111/j.1749-6632.1979.tb56544.x. View

19.

Hunter D, Haworth R . The Ca2+-induced membrane transition in mitochondria. I. The protective mechanisms. Arch Biochem Biophys. 1979; 195(2):453-9. DOI: 10.1016/0003-9861(79)90371-0. View

20.

Carafoli E . The calcium cycle of mitochondria. FEBS Lett. 1979; 104(1):1-5. DOI: 10.1016/0014-5793(79)81073-x. View