Article: Venous prostaglandin-like activity in diarrhoeal states

Prostaglandin E2-like activity was determined in peripheral venous blood of control subjects and in patients with acute gastroenteritis and active ulcerative colitis, using a bioassay method. No significant diurnal variations of prostaglandin levels were detected in the control group, while significantly raised venous plasma prostaglandin-like activity was detected in acute gastroenteritis and in active ulcerative colitis.

Citing Articles

Effect of prednisolone on prostaglandin synthesis by rectal mucosa in ulcerative colitis: investigation by laminar flow bioassay and radioimmunoassay.

Hawkey C, TRUELOVE S Gut. 1981; 22(3):190-3.

PMID: 7227851 PMC: 1419508. DOI: 10.1136/gut.22.3.190.

Changes in colonic tissue levels of inflammatory mediators in a guinea-pig model of immune colitis.

Norris A, Lewis A, Zeitlin I Agents Actions. 1982; 12(1-2):243-6.

PMID: 6952749 DOI: 10.1007/BF01965154.

Prostaglandins and ulcerative colitis.

Rampton D, Hawkey C Gut. 1984; 25(12):1399-413.

PMID: 6150882 PMC: 1420195. DOI: 10.1136/gut.25.12.1399.

Prostaglandin synthetase activity in acute ulcerative colitis: effects of treatment with sulphasalazine, codeine phosphate and prednisolone.

Smith P, Dawson D, Swan C Gut. 1979; 20(9):802-5.

PMID: 40848 PMC: 1412641. DOI: 10.1136/gut.20.9.802.

References

1.

Green K, Samuelsson B . PROSTAGLANDINS AND RELATED FACTORS: XIX. THIN-LAYER CHROMATOGRAPHY OF PROSTAGLANDINS. J Lipid Res. 1964; 5:117-20. View

2.

Saeed S, CUTHBERT J, Copas J, Schneider C, Gardiner P, Butt N . Endogenous inhibitor of prostaglandin synthetase. Nature. 1977; 270(5632):32-6. DOI: 10.1038/270032a0. View

3.

Ferreira S . Prostaglandins, aspirin-like drugs and analgesia. Nat New Biol. 1972; 240(102):200-3. DOI: 10.1038/newbio240200a0. View

4.

Williams E, Karim S, Sandler M . Prostaglandin secretion by medullary carcinoma of the thyroid. A possible cause of the associated idarrhoea. Lancet. 1968; 1(7532):22-3. DOI: 10.1016/s0140-6736(68)90010-x. View

5.

Misiewicz J, Waller S, Kiley N . Effect of oral prostaglandin E1 on intestinal transit in man. Lancet. 1969; 1(7596):648-51. DOI: 10.1016/s0140-6736(69)92012-1. View

6.

Sandler M, Karim S, Williams E . Prostaglandins in amine-peptide-secreting tumours. Lancet. 1968; 2(7577):1053-4. DOI: 10.1016/s0140-6736(68)91528-6. View

7.

Giroud J, Willoughby D . The interrelations of complement and a prostaglandin-like substance in acute inflammation. J Pathol. 1970; 101(3):241-9. DOI: 10.1002/path.1711010306. View

8.

JACOBY H, Marshall C . Antagonism of cholera enterotoxin by anti-inflammatory agents in the rat. Nature. 1972; 235(5334):163-5. DOI: 10.1038/235163a0. View

9.

Finck A, Katz R . Prevention of cholera-induced intestinal secretion in the cat by aspirin. Nature. 1972; 238(5362):273-4. DOI: 10.1038/238273a0. View

10.

Piper P, Vane J, Wyllie J . Inactivation of prostaglandins by the lungs. Nature. 1970; 225(5233):600-4. DOI: 10.1038/225600a0. View

11.

Greaves M, Sondergaard J . Recovery of prostaglandins in human cutaneous inflammation. Br Med J. 1971; 2(5756):258-60. PMC: 1796440. DOI: 10.1136/bmj.2.5756.258. View

12.

Karim S . Effects of oral administration of prostaglandins E 2 and F 2- on the human uterus. J Obstet Gynaecol Br Commonw. 1971; 78(4):289-93. DOI: 10.1111/j.1471-0528.1971.tb00274.x. View

13.

Karim S, Filshie G . Therapeutic abortion using prostaglandin F2alpha. Lancet. 1970; 1(7639):157-9. DOI: 10.1016/s0140-6736(70)90402-2. View

Venous Prostaglandin-like Activity in Diarrhoeal States