Prostaglandin Synthetase Activity in Acute Ulcerative Colitis: Effects of Treatment with Sulphasalazine, Codeine Phosphate and Prednisolone

Overview

Journal Gut

Specialty Gastroenterology

Date 1979 Sep 1

PMID 40848

Citations 26

Authors

P R Smith

D J Dawson

C H Swan

Affiliations

Soon will be listed here.

Abstract

Prostaglandin synthetase activity in rectal biopsy specimens from patients with ulcerative colitis has been shown to fall on treatment with sulphasalazine, local steroids, and codeine phosphate. In vitro studies have shown that sulphasalazine is an inhibitor of prostaglandin synthetase, although less potent than indomethacin, whereas prednisolone and codeine phosphate were inactive. It is suggested that the therapeutic action of sulphasalazine may be related in part to its action in inhibiting prostaglandin biosynthesis.

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