Conserved Repeated DNA Sequences in Vertebrate Sex Chromosomes

Overview

Journal Hum Genet

Specialty Genetics

Date 1981 Jan 1

PMID 7286992

Citations 29

Authors

K W Jones

L Singh

Affiliations

Soon will be listed here.

Abstract

Satellite DNA isolated from female Elapid snakes contains nucleotide sequences which are quantitatively derived from the W sex-determining chromosome. Certain of these sequences are highly conserved in vertebrates, including mammals, where they are arranged in a sex-specific pattern in Southern blots. Sex reversed mice (Sxr) show a DNA arrangement of these sequences in conformity with their phenotypic sex, suggesting that this DNA is closely connected with the determination of sex. In situ hybridization of the snake sequences with mouse chromosomes reveals a concentration of related DNA at the proximal tip of the mouse Y chromosome. This possible nature and significance of these observations is discussed.

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