The Effects of Pentobarbitone and Urethane on Pulmonary Airway Resistance in Guinea-pigs and Their Interactions with Drugs

Overview

Journal Br J Pharmacol

Publisher Wiley

Specialty Pharmacology

Date 1978 Dec 1

PMID 728681

Citations 5

Authors

C Advenier

J R BOISSIER

S Ho

B Mallard

F Ruff

Affiliations

Soon will be listed here.

Abstract

1 Propranolol increased pulmonary airway resistance (PAR) in the conscious guinea-pig, whereas atropine had no effect, suggesting the existence of a continual sympathetic bronchodilator tone. 2 The direct bronchoconstrictor effects of histamine, acetylcholine and 5-hydroxytryptamine were modified by autonomic reflexes: a bronchodilator one, abolished by propranolol, and a cholinergic bronchoconstrictor one, seen with histamine. 3 Pentobarbitone increased PAR, an effect which was reduced by propranolol but which was unaffected by atropine. The bronchoconstrictor effects of histamine, acetylcholine and 5-hydroxytryptamine were potentiated by pentobarbitone. 4 Pentobarbitone therefore appears to inhibit the adrenergic bronchodilator tone and to depress adrenergic reflexes, these being the preponderant autonomic influences in these experiments. 5 Like pentobarbitone, urethane increased PAR in the conscious guinea-pig and potentiated the bronchoconstrictor effects of the three amines. These actions are similarly attributed to a reduction in adrenergic influences.

Citing Articles

The effect of urethane on histamine-induced contraction of guinea-pig tracheal smooth muscle.

Maggi C, Santicioli P, Evangelista S, Meli A Experientia. 1982; 38(12):1474-6.

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The effects of atropine on anaphylactic shock in the guinea-pig.

Advenier C, Mallard B, Santais M, Ruff F Agents Actions. 1982; 12(1-2):103-7.

PMID: 6282070 DOI: 10.1007/BF01965117.

Differences in cardiovascular responses to peripherally administered GABA as influenced by basal conditions and type of anaesthesia.

Giuliani S, Maggi C, Meli A Br J Pharmacol. 1986; 88(3):659-70.

PMID: 3742154 PMC: 1916971. DOI: 10.1111/j.1476-5381.1986.tb10248.x.

Suitability of urethane anesthesia for physiopharmacological investigations. Part 3: Other systems and conclusions.

Maggi C, Meli A Experientia. 1986; 42(5):531-7.

PMID: 3519271 DOI: 10.1007/BF01946692.

The effects of metiamide and H1 receptor blocking agents on anaphylactic response in guinea-pigs.

Advenier C, Mallard B, Santais M, Ruff F Agents Actions. 1979; 9(5-6):467-73.

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References

BAISSET A, Laporte Y, MONTASTRUC P . [Experimental contribution to the study of the effects of urethane on the general circulatory reflexes]. Therapie. 1959; 14:1053-67. View

McCulloch M, Proctor C, Rand M . Evidence for an adrenergic homeostatic bronchodilator reflex mechanism. Eur J Pharmacol. 1967; 2(3):214-23. DOI: 10.1016/0014-2999(67)90090-8. View

Nadel J . STRUCTURE-FUNCTION RELATIONSHIPS IN THE AIRWAYS: BRONCHOCONSTRICTION MEDIATED VIA VAGUS NERVES OR BRONCHIAL ARTERIES; PERIPHERAL LUNG CONSTRICTION MEDIATED VIA PULMONARY ARTERIES. Med Thorac. 1965; 22:231-43. View

Amdur M, Mead J . Mechanics of respiration in unanesthetized guinea pigs. Am J Physiol. 1958; 192(2):364-8. DOI: 10.1152/ajplegacy.1958.192.2.364. View

HERXHEIMER H . Bronchoconstrictor agents and their antagonists in the intact guinea-pig. Arch Int Pharmacodyn Ther. 1956; 106(4):371-80. View

EXLEY K . Depression of autonomic ganglia by barbiturates. Br J Pharmacol Chemother. 1954; 9(2):170-81. PMC: 1509423. DOI: 10.1111/j.1476-5381.1954.tb00837.x. View

HOKFELT B, McLean J . The adrenaline and noradrenaline content of the rabbit under normal conditions and after various forms of stimulation. Acta Physiol Scand. 1950; 21(2-3):258-70. DOI: 10.1111/j.1748-1716.1950.tb00734.x. View

Jackson D, Richards I . The effects of pentobarbitone and chloralose anaesthesia on the vagal component of bronchoconstriction produced by histamine aerosol in the anaesthetized dog. Br J Pharmacol. 1977; 61(2):251-6. PMC: 1667511. DOI: 10.1111/j.1476-5381.1977.tb08412.x. View

DeKock M, Nadel J, ZWI S, COLEBATCH H, Olsen C . New method for perfusing bronchial arteries: histamine bronchoconstriction and apnea. J Appl Physiol. 1966; 21(1):185-94. DOI: 10.1152/jappl.1966.21.1.185. View

10.

ODonnell S, Saar N . A histochemical study of extraneuronal accumulation of noradrenaline in the guinea-pig trachea. Br J Pharmacol. 1973; 49(2):267-78. PMC: 1776373. DOI: 10.1111/j.1476-5381.1973.tb08372.x. View

11.

Douglas J, Dennis M, Ridgway P, Bouhuys A . Airway dilatation and constriction in spontaneously breathing guinea pigs. J Pharmacol Exp Ther. 1972; 180(1):98-109. View

12.

Coleman R, Levy G . A non-adrenergic inhibitory nervous pathway in guinea-pig trachea. Br J Pharmacol. 1974; 52(2):167-74. PMC: 1776879. DOI: 10.1111/j.1476-5381.1974.tb09697.x. View

13.

Advenier C, BOISSIER J, Giudicelli J . Comparative study of six -adrenoceptive antagonists on airway resistance and heart rate in the guinea-pig. Br J Pharmacol. 1972; 44(4):642-50. PMC: 1665988. DOI: 10.1111/j.1476-5381.1972.tb07304.x. View

14.

Barrett A . The effects of some autonomic blocking agents on the heart rate of anesthetized and pithed rats. Eur J Pharmacol. 1971; 15(3):267-73. DOI: 10.1016/0014-2999(71)90092-6. View

15.

COBURN R, Tomita T . Evidence for nonadrenergic inhibitory nerves in the guinea pig trachealis muscle. Am J Physiol. 1973; 224(5):1072-80. DOI: 10.1152/ajplegacy.1973.224.5.1072. View

16.

James G . The role of the adrenal glands and of alpha- and beta-adrenergic receptors in bronchodilatation of guinea-pig lungs in vivo. J Pharm Pharmacol. 1967; 19(12):797-802. DOI: 10.1111/j.2042-7158.1967.tb09546.x. View

17.

Bunag R, Mullenix P . Augmentation of drug-induced blood pressure increases in rats by amorbarbital. Br J Pharmacol. 1972; 46(3):511-3. PMC: 1666504. DOI: 10.1111/j.1476-5381.1972.tb08149.x. View

18.

Holmes J, SCHNEIDER F . Pentobarbitone inhibition of catecholamine secretion. Br J Pharmacol. 1973; 49(2):205-13. PMC: 1776387. DOI: 10.1111/j.1476-5381.1973.tb08366.x. View

19.

BUNAG R, Eferakeya J . Reduced cardiovascular responsiveness to hypothalamic stimulation during urethane and amobarbital anesthesia. Pharmacology. 1973; 10(3):143-51. DOI: 10.1159/000136434. View

20.

Douglas J, Dennis M, Ridgway P, Bouhuys A . Airway constriction in guinea pigs: interaction of histamine and autonomic drugs. J Pharmacol Exp Ther. 1973; 184(1):169-79. View