Expression of Resistance to Friend Virus-stimulated Erythropoiesis in Bone Marrow Chimeras Containing Fv-2rr and Fv-2ss Bone Marrow

Overview

Journal J Exp Med

Specialties Allergy & Immunology
General Medicine

Date 1981 Jul 1

PMID 7252425

Citations 6

Authors

J Silver

N Teich

Affiliations

Soon will be listed here.

Abstract

Bone marrow chimeras were formed containing mixtures of DBA/2 (Fv-2ss, Hbbdd) and B10.D2 (Fv-2rr, Hbbss) bone marrow. When these mice were infected with the polycythemia-inducing strain of Friend virus, erythropoiesis was stimulated, but the proportion of B10.D2 hemoglobin fell rapidly and newly synthesized hemoglobin was essentially all of the DBA/2 type. The treatment of infected polycythemic chimeras with phenylhydrazine lowered the hematocrit and restored the synthesis of B10.D2 hemoglobin. These results imply that B10.D2 erythroid precursors are intrinsically resistant to Friend virus-stimulated erythropoiesis. The experiments also suggest that virus-stimulated erythropoiesis is not mediated by a factor or cell-cell interactions, unless such factors or interactions do not act across strain barriers.

Citing Articles

The envelope glycoprotein of friend spleen focus-forming virus covalently interacts with and constitutively activates a truncated form of the receptor tyrosine kinase Stk.

Nishigaki K, Thompson D, Hanson C, Yugawa T, Ruscetti S J Virol. 2001; 75(17):7893-903.

PMID: 11483734 PMC: 115033. DOI: 10.1128/jvi.75.17.7893-7903.2001.

Lymphocyte deficiencies increase susceptibility to friend virus-induced erythroleukemia in Fv-2 genetically resistant mice.

Hasenkrug K J Virol. 1999; 73(8):6468-73.

PMID: 10400741 PMC: 112728. DOI: 10.1128/JVI.73.8.6468-6473.1999.

A genetic linkage map of the mouse chromosome 9 region encompassing the Friend virus susceptibility gene 2.

Paulson R, Bernstein A Mamm Genome. 1998; 9(5):381-4.

PMID: 9545496 DOI: 10.1007/s003359900774.

A Friend virus mutant that overcomes Fv-2rr host resistance encodes a small glycoprotein that dimerizes, is processed to cell surfaces, and specifically activates erythropoietin receptors.

Kozak S, Hoatlin M, Ferro Jr F, Majumdar M, Geib R, Fox M J Virol. 1993; 67(5):2611-20.

PMID: 8474164 PMC: 237582. DOI: 10.1128/JVI.67.5.2611-2620.1993.

Activation of erythropoietin receptors by Friend viral gp55 and by erythropoietin and down-modulation by the murine Fv-2r resistance gene.

Hoatlin M, Kozak S, Lilly F, Chakraborti A, Kozak C, Kabat D Proc Natl Acad Sci U S A. 1990; 87(24):9985-9.

PMID: 2175917 PMC: 55299. DOI: 10.1073/pnas.87.24.9985.

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