Influence of Arteriographic Contrast Media on the Na+/Ca++-ratio in Blood

Overview

Journal Cardiovasc Intervent Radiol

Specialty Cardiology & Vascular Diseases

Date 1981 Jan 1

PMID 7249012

Citations 1

Authors

H G Wolpers

D Baller

F B Ensink

W Schroter

J Zipfel

G Hellige

Affiliations

Soon will be listed here.

Abstract

To investigate the basis of cardiodepressive side effects in coronary arteriography, the isolated effects of different contrast media on electrolyte levels in blood (and blood fractions) were quantified in vitro. Due to their sodium content and calcium chelation, ionic media cause an imbalance in the extracellar Na+/Ca++-ratio that determines myocardial contractility. Ca++-chelation exceeded that due to stabilizing additives indicating a binding by the contrast agents themselves. The amount of calcium bound varied with different media and was greatest with Renografin. It is suggested that the degree of Na+/Ca++-imbalance in blood explains the extent of acute cardiodepression.

Citing Articles

Elimination of variable vasomotor tone in studies with repeated quantitative coronary angiography.

Jost S, Rafflenbeul W, Reil G, Trappe H, Gulba D, Hecker H Int J Card Imaging. 1990; 5(2-3):125-34.

PMID: 2121843 DOI: 10.1007/BF01833981.

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