Effects of the Landschütz Ascites Carcinoma and Ascitic Fluid on Macrophage Activity in C. Parvum-injected Mice

Overview

Journal Br J Cancer

Specialty Oncology

Date 1981 Apr 1

PMID 7236491

Citations 3

Authors

L C McIntosh

A W Thomson

Affiliations

Soon will be listed here.

Abstract

I.p. administration of 1.4 mg Corynebacterium parvum (C. parvum) 24 h before inoculation of Landschütz ascites carcinoma (LAC) cells significantly impaired growth of the tumour in MF1 mice. The injection of tumour cells caused a transient inhibition of the activity of the mononuclear phagocyte system (MPS) in both normal and C. parvum-treated hosts, as evidenced by impaired clearance of colloidal carbon from the bloodstream and reduction in hepatic phagocytosis of 51Cr-labelled sheep erythrocytes. Depression in Kupffer-cell activity was associated with a shift in particle distribution towards the spleen. The pronounced hepatosplenomegaly in response to C. parvum was significantly less in animals which also received tumour cells. Histological examination of liver and spleen revealed evidence of depressed MPS activity. Granuloma production in the liver in response to C. parvum was inhibited in tumour-bearing mice, and macrophage proliferation within the spleen was also reduced. Ascitic fluid showed similar inhibitory effects to those of tumour-cell suspensions, suggesting production by LAC of a heat-stable macrophage-inhibitory factor.

Citing Articles

Serum biochemical changes in c. parvum-injected mice bearing the Landschütz ascites carcinoma.

McIntosh L, Thomson A, Whiting P Br J Exp Pathol. 1982; 63(6):639-43.

PMID: 7150511 PMC: 2040701.

Inhibition by the Landschütz ascites carcinoma of the granulomatous inflammatory response to C. parvum.

McIntosh L, Fraser R, Thomson A Br J Cancer. 1982; 45(4):598-612.

PMID: 7073950 PMC: 2010992. DOI: 10.1038/bjc.1982.97.

Influence of tumour carriage on the production of lymphokines affecting macrophage behaviour.

McIntosh L, Morrice L, Udagawa Y, Thomson A Immunology. 1986; 57(3):359-65.

PMID: 3485563 PMC: 1453823.

References

McCarthy R, Coffin J, Gates S . Selective inhibition of the secondary immune response to mouse skin allografts by cell-free Ehrlich ascites carcinoma fluid. Transplantation. 1968; 6(5):737-43. DOI: 10.1097/00007890-196808000-00006. View

Levy M, Wheelock E . The role of macrophages in defense against neoplastic disease. Adv Cancer Res. 1974; 20:131-63. DOI: 10.1016/s0065-230x(08)60110-4. View

McBride W, Jones J, WEIR D . Increased phagocytic cell activity and anaemia in Corynebacterium parvum treated mice. Br J Exp Pathol. 1974; 55(1):38-46. PMC: 2072669. View

Eccles S, Alexander P . Sequestration of macrophages in growing tumours and its effect on the immunological capacity of the host. Br J Cancer. 1974; 30(1):42-9. PMC: 2009196. DOI: 10.1038/bjc.1974.111. View

Hrsak I, Marotti T . Immunosuppression mediated by Ehrlich ascites fluid. Eur J Cancer (1965). 1973; 9(10):717-24. DOI: 10.1016/0014-2964(73)90061-3. View

Hrsak I, Marotti T . Mode of immunosuppressive action of Ehrlich ascitic fluid. J Natl Cancer Inst. 1974; 53(4):1113-9. DOI: 10.1093/jnci/53.4.1113. View

Levy M, Wheelock E . Effects of intravenous silica on immune and non-immune functions of the murine host. J Immunol. 1975; 115(1):41-8. View

Sljivic V, Warr G . Role of cellular proliferation in the stimulation of MPS phagocytic activity. Br J Exp Pathol. 1975; 56(4):314-21. PMC: 2072766. View

NORTH R, Kirstein D, TUTTLE R . Subversion of host defense mechanisms by murine tumors. I. A circulating factor that suppresses macrophage-mediated resistance to infection. J Exp Med. 1976; 143(3):559-73. PMC: 2190133. DOI: 10.1084/jem.143.3.559. View

10.

Snyderman R, Pike M, Blaylock B, Weinstein P . Effects of neoplasms on inflammation: depression of macrophage accumulation after tumor implantation. J Immunol. 1976; 116(3):585-9. View

11.

Alexander P . The functions of the macrophage in malignant disease. Annu Rev Med. 1976; 27:207-24. DOI: 10.1146/annurev.me.27.020176.001231. View

12.

Pike M, Snyderman R . Depression of macrophage function by a factor produced by neoplasms: a merchanism for abrogation of immune surveillance. J Immunol. 1976; 117(4):1243-9. View

13.

Norman S, Sorkin E . Cell-specific defect in monocyte function during tumor growth. J Natl Cancer Inst. 1976; 57(1):135-40. DOI: 10.1093/jnci/57.1.135. View

14.

Snyderman R, Seigler H, Meadows L . Abnormalitieis of monocyte chemotaxis in patients with melanoma: effects of immunotherapy and tumor removal. J Natl Cancer Inst. 1977; 58(1):37-41. DOI: 10.1093/jnci/58.1.37. View

15.

Otu A, Russell R, White R . Biphasic pattern of activation of the reticuloendothelial system by anaerobic coryneforms in mice. Immunology. 1977; 32(3):255-64. PMC: 1445279. View

16.

Meltzer M, Stevenson M . Macrophage function in tumor-bearing mice: tumoricidal and chemotactic responses of macrophages activated by infection with Mycobacterium bovis, strain BCG. J Immunol. 1977; 118(6):2176-81. View

17.

Otu A, Russell R, Wilkinson P, White R . Alterations of mononuclear phagocyte function induced by Lewis lung carcinoma in C57BL mice. Br J Cancer. 1977; 36(3):330-40. PMC: 2025419. DOI: 10.1038/bjc.1977.197. View

18.

Nelson M, Nelson D . Macrophages and resistance to tumours. I. Inhibition of delayed-type hypersensitivity reactions by tumour cells and by soluble prducts affecting macrophages. Immunology. 1978; 34(2):277-90. PMC: 1457692. View

19.

Milas L, Scott M . Antitumor activity of Corynebacterium parvum. Adv Cancer Res. 1978; 26:257-306. DOI: 10.1016/s0065-230x(08)60090-1. View

20.

Normann S . Tumor cell threshold required for suppression of macrophage inflammation. J Natl Cancer Inst. 1978; 60(5):1091-6. DOI: 10.1093/jnci/60.5.1091. View