A W Thomson
Overview
Explore the profile of A W Thomson including associated specialties, affiliations and a list of published articles.
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Articles
411
Citations
4126
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Recent Articles
1.
Perez-Gutierrez A, Metes D, Lu L, Hariharan S, Thomson A, Ezzelarab M
Clin Exp Immunol
. 2018 Sep;
194(2):259-272.
PMID: 30246373
Memory T cell (Tmem) responses play a critical role in the outcome of allo-transplantation. While the role of the T-box transcription factor Eomesodermin (Eomes) in the maintenance of antigen-specific Tmem...
2.
Thomson A, Ezzelarab M
Am J Transplant
. 2017 Feb;
17(5):1156-1157.
PMID: 28141921
No abstract available.
3.
Ezzelarab M, Raich-Regue D, Lu L, Zahorchak A, Perez-Gutierrez A, Humar A, et al.
Am J Transplant
. 2016 Dec;
17(6):1476-1489.
PMID: 28009481
Systemic administration of autologous regulatory dendritic cells (DCreg; unpulsed or pulsed with donor antigen [Ag]), prolongs allograft survival and promotes transplant tolerance in rodents. Here, we demonstrate that nonhuman primate...
4.
Guo H, Lu L, Wang R, Perez-Gutierrez A, Abdulkerim H, Zahorchak A, et al.
Am J Transplant
. 2016 May;
16(10):2994-3006.
PMID: 27217298
Transforming growth factor β1 (TGFβ1) plays a key role in T cell homeostasis and peripheral tolerance. We evaluated the influence of a novel human mutant TGFβ1/Fc (human IgG4 Fc) fusion...
5.
Ezzelarab M, Zhang H, Guo H, Lu L, Zahorchak A, Wiseman R, et al.
Am J Transplant
. 2015 Dec;
16(7):1999-2015.
PMID: 26700196
The ability of regulatory T cells (Treg) to prolong allograft survival and promote transplant tolerance in lymphodepleted rodents is well established. Few studies, however, have addressed the therapeutic potential of...
6.
Zahorchak A, Ezzelarab M, Lu L, Turnquist H, Thomson A
Am J Transplant
. 2015 Sep;
16(2):661-71.
PMID: 26372923
Increasing evidence from small animal models shows that myeloid-derived suppressor cells (MDSCs) can play a crucial role in inhibiting allograft rejection and promoting transplant tolerance. We identified CD3(-)CD20(-)HLA-DR(-)CD14(+)CD33(+)CD11b(+) cells in...
7.
Fishman J, Thomson A
Am J Transplant
. 2015 Mar;
15(7):1755-8.
PMID: 25810247
Links between the human microbiome and the innate and adaptive immune systems and their impact on autoimmune and inflammatory diseases are only beginning to be recognized. Characterization of the complex...
8.
Zhang H, Guo H, Lu L, Zahorchak A, Wiseman R, Raimondi G, et al.
Am J Transplant
. 2015 Mar;
15(5):1253-66.
PMID: 25783759
Ex vivo-expanded cynomolgus monkey CD4(+)CD25(+)CD127(-) regulatory T cells (Treg) maintained Foxp3 demethylation status at the Treg-specific demethylation region, and potently suppressed T cell proliferation through three rounds of expansion. When...
9.
Fantus D, Thomson A
Am J Transplant
. 2015 Mar;
15(4):891-902.
PMID: 25737114
Since the discovery of Rapamycin (RAPA) and its immunosuppressive properties, enormous progress has been made in characterizing the mechanistic target of rapamycin (mTOR). Use of RAPA and its analogues (rapalogs)...
10.
Rosborough B, Raich-Regue D, Liu Q, Venkataramanan R, Turnquist H, Thomson A
Am J Transplant
. 2014 Oct;
14(9):2173-80.
PMID: 25307040
The mechanistic/mammalian target of rapamycin (mTOR) is inhibited clinically to suppress T cell function and prevent allograft rejection. mTOR is the kinase subunit of two mTOR-containing complexes, mTOR complex (mTORC)...