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Inhibition of Gastric Acid Secretion with a Mast Cell Stabiliser, FPL-52694

Overview
Journal Br J Clin Pharmacol
Specialty Pharmacology
Date 1981 Jan 1
PMID 7213509
Citations 8
Authors
H A Davies
J Rhodes
M Thomas
Affiliations
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Abstract

1 The effect on gastric acid secretion of a mast cell stabiliser FPL-52694 was examined in nine healthy volunteers. 2 The compound which is moderately well absorbed after oral ingestion, was taken for 5 days prior to the measurement of acid secretion and was also given intravenously during part of the gastric test. A submaximal dose of pentagastrin (0.3 microgram/kg/h) was given by intravenous infusion for 2 h in a controlled test and then after administration of FPL-52694. 3 There was a significant reduction (37%) in acid secretion during the second test which was probably due to the effect of the compound on mast cell degranulation in the gastric mucosa.

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Inhibition of gastric acid secretion in the conscious dog by the mast-cell stabilizing agent, FPL 52694.

Canfield S, Curwain B Br J Pharmacol. 1983; 80(1):27-32.

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Effects of FPL-52694, a new mast cell stabilizer, on gastric secretion and various acute gastric lesions in rats.

Takeuchi K, Ishihara Y, Kunimi H, Okabe S Agents Actions. 1984; 14(5-6):637-42.

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Action of FPL 52694 on gastric acid secretion in the healthy human stomach.

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