Action of FPL 52694 on Gastric Acid Secretion in the Healthy Human Stomach

Overview

Journal Gut

Specialty Gastroenterology

Date 1984 Nov 1

PMID 6500362

Citations 1

Authors

H J Reimann

U Schmidt

B Ultsch

T J Sullivan

P Wendt

Affiliations

Soon will be listed here.

Abstract

In a double blind crossover experiment in 16 healthy male volunteers, the effects of oral FPL 52694 and a matching placebo upon pentagastrin stimulated gastric acid secretion, gastric mucosal histamine content, and gastric mucosal mast cell count were compared. There was a significant increase in acid secretion, and a fall in tissue histamine and the mast cell count after treatment with the placebo. All these changes were inhibited by FPL 52694, and there was a significant difference between the effects of this compound and the placebo in all three parameters. It is concluded that FPL 52694 caused significant inhibition of acid secretion, and that the likely mechanism of action is by stabilisation of mast cells and inhibition of histamine release.

Citing Articles

Effects of a mast cell stabiliser (FPL 52694) on human gastric secretion.

Boyd E, Wilson J, Wormsley K, Richards M, Langman M Agents Actions. 1985; 16(6):462-7.

PMID: 4072827 DOI: 10.1007/BF01983647.

References

Ehinger B, Hakanson R, Owman C, Sporrong B . Histochemical demonstration of histamine in paraffin sections by a fluorescence method. Biochem Pharmacol. 1968; 17(9):1997-8. DOI: 10.1016/0006-2952(68)90116-0. View

Cox J . Disodium cromoglycate. Mode of action and its possible relevance to the clinical use of the drug. Br J Dis Chest. 1971; 65(4):189-204. DOI: 10.1016/0007-0971(71)90028-3. View

Black J, Duncan W, Durant C, Ganellin C, Parsons E . Definition and antagonism of histamine H 2 -receptors. Nature. 1972; 236(5347):385-90. DOI: 10.1038/236385a0. View

Lorenz W, Reimann H, Barth H, Kusche J, Meyer R, Doenicke A . A sensitive and specific method for the determination of histomine in human whole blood and plasma. Hoppe Seylers Z Physiol Chem. 1972; 353(6):911-20. DOI: 10.1515/bchm2.1972.353.1.911. View

Reimann H, Lorenz W, Fischer M, Frolich R, Meyer H, SCHMAL A . Histamine and acute haemorrhagic lesions in rat gastric mucosa: prevention of stress ulcer formation by (+)-catechin, an inhibitor of specific histidine decarboxylase in vitro. Agents Actions. 1977; 7(1):69-73. DOI: 10.1007/BF01964883. View