Transplantable IgD Immunoglobulin-secreting Tumors in Rat

Overview

Journal J Immunol

Specialty Allergy & Immunology

Date 1978 Nov 1

PMID 712079

Citations 14

Authors

H Bazin

A Beckers

R Pauwels

C Bruyns

A F Tilkin

B Platteau

J Urbain

Affiliations

Soon will be listed here.

Abstract

The LOU/C/Wsl rat inbred strain presents a high incidence of spontaneous malignant ileocecal immunocytomas or monoclonal immunoglobulin-secreting tumors. Some tumors have been transplanted in histocompatible animals over years without any change in their secretion products. Among approximately 600 different monoclonal proteins we have studied so far, we recognized six showing properties different from those of rat IgM, IgA, IgE, or IgG classes, and characteristic of the IgD class.

Citing Articles

Differentiation of membrane IgE+ rat B cells into IgE-secreting cells.

Vanhove B, Bazin H Immunology. 1993; 79(4):580-6.

PMID: 8406582 PMC: 1421915.

The biological half-lives of four rat immunoglobulin isotypes.

Peppard J, ORLANS E Immunology. 1980; 40(4):683-6.

PMID: 7429545 PMC: 1458093.

Augmentation of in vitro humoral immune responses in the mouse by an antibody to IgD.

Finkelham F, Woods V, Wilburn S, Mond J, STEIN K, Berning A J Exp Med. 1980; 152(3):493-506.

PMID: 6967945 PMC: 2185918. DOI: 10.1084/jem.152.3.493.

Switch from hapten-specific immunoglobulin M to immunoglobulin D secretion in a hybrid mouse cell line.

Neuberger M, Rajewsky K Proc Natl Acad Sci U S A. 1981; 78(2):1138-42.

PMID: 6940132 PMC: 319962. DOI: 10.1073/pnas.78.2.1138.

Mouse immunoglobulin D: construction and characterization of a cloned delta chain cDNA.

MUSHINSKI J, Blattner F, Owens J, Finkelman F, Kessler S, Fitzmaurice L Proc Natl Acad Sci U S A. 1980; 77(12):7405-9.

PMID: 6784124 PMC: 350512. DOI: 10.1073/pnas.77.12.7405.