Sister Chromatid Exchanges in Leukocytes of Patients with Cancer of Cervix Uteri

Overview

Journal Hum Genet

Specialty Genetics

Date 1982 Jan 1

PMID 7106751

Citations 4

Authors

A B Mitra

V V Murty

U K Luthra

Affiliations

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Abstract

The frequency of sister chromatid exchange (SCE) was investigated in 13 women with cervical cancer together with 11 control women. The SCE frequencies were found to be 10.05 +/- 2.35 and 6.95 +/- 1.53 in cancer cases and controls, respectively. The SCE values of cancer cases deviate significantly from that of controls. The SCE in chromosome groups E, F, and G was found to be more in comparison to controls (P less than 0.001). This preliminary study indicates the possibility of using SCE as a preclinical marker.

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