The Effect of Pindolol on Myocardial Blood Flow, Metabolism and Function During Rest and Pacing in Patients with Coronary Heart Disease

Overview

Journal Br J Clin Pharmacol

Specialty Pharmacology

Date 1982 Jan 1

PMID 7104152

Citations 1

Authors

W Kupper

C W Hamm

W BLEIFELD

Affiliations

Soon will be listed here.

Abstract

1 The study was designed to elucidate further the mechanism by which beta-adrenoceptor antagonism with pindolol relieves the symptoms of angina pectoris in patients with coronary heart disease. 2 Pindolol administration was associated with an elevated threshold for angina pectoris and improved myocardial lactate metabolism during supraventricular pacing. 3 This beneficial effect of pindolol was independent of changes in myocardial blood flow and was not mediated by haemodynamic effects. 4 The results suggest that in angina pectoris, in addition to the recognized beneficial effects of beta-adrenoceptor blockade, the actions of pindolol also result from, as yet, poorly described phenomena such as redistribution of myocardial blood flow or metabolic effects.

Citing Articles

Effect of adrenaline on myocardial oxygen consumption during selective and non-selective beta-adrenoceptor blockade comparison of atenolol and pindolol.

Ihlen H, Simonsen S, Welzel D Eur J Clin Pharmacol. 1984; 27(1):29-34.

PMID: 6489425

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