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Multicentre Post-infarction Trial of Propranolol in 49 Hospitals in the United Kingdom, Italy, and Yugoslavia

Overview
Journal Br Heart J
Specialty Cardiology & Vascular Diseases
Date 1980 Jul 1
PMID 7000100
Citations 21
Authors
N S Baber
D W Evans
G Howitt
M Thomas
T Wilson
J A Lewis
P M Dawes
K Handler
R Tuson
Affiliations
Soon will be listed here.
Abstract

A multicentre study of survivors of an anterior myocardial infarction is reported. The trial consisted of 720 patients and was a double-blind, placebo-controlled study with propranolol 40 mg three times a day. Trial entry was at two to 14 days (mean 8.5 days) and follow-up at one, three, and in most centres, six and nine months. The trial was designed to detect a 50 per cent reduction in mortality and this was not shown. The non-fatal reinfarction rate was similar in both groups. Subgroup analysis identified several prognostic risk factors for death, none of which interacted with treatment.

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References
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