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Hydrolysis of Milk Fat Globules by Pancreatic Lipase. Role of Colipase, Phospholipase A2, and Bile Salts

Overview
Journal J Clin Invest
Specialty General Medicine
Date 1982 Jul 1
PMID 7085886
Citations 8
Authors
B Borgstrom
C Erlanson-Albertsson
Affiliations
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Abstract

Human milk fat globules require colipase to be hydrolyzed by pancreatic lipase in the presence of bile salts. This is contrary to a recent report in this Journal (J. Clin. Invest. 67: 1748-1752.) according to which inhibition of lipase by bile salt could be overcome by the addition of colipase or phospholipase A2. This latter finding is shown to be due to contamination of commercially available pancreatic phospholipase A2 by colipase.

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References
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Brogstrom B, Hildebrand H . Lipase and co-lipase activities of human small intestinal contents after a liquid test meal. Scand J Gastroenterol. 1975; 10(6):585-91. View
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Donner J . Preparation of porcine pancreatic lipase free of co-lipase activity. Acta Chem Scand B. 1976; 30(5):430-4. DOI: 10.3891/acta.chem.scand.30b-0430. View
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Canioni P, Julien R, Rathelot J, Sarda L . Pancreatic and microbial lipases: a comparison of the interaction of pancreatic colipase with lipases of various origins. Lipids. 1977; 12(4):393-7. DOI: 10.1007/BF02533644. View
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Borgstrom B, Erlanson-Albertsson C, Wieloch T . Pancreatic colipase: chemistry and physiology. J Lipid Res. 1979; 20(7):805-16. View