Enteropathy of Coeliac Disease in Adults: Increased Number of Enterochromaffin Cells the Duodenal Mucosa

Overview

Journal Gut

Specialty Gastroenterology

Date 1982 Jan 1

PMID 7056495

Citations 16

Authors

K Sjolund

J Alumets

N O BERG

R Hakanson

F Sundler

Affiliations

Soon will be listed here.

Abstract

Twenty-nine adult patients with coeliac disease and 39 patients with a normal duodenal morphology were studied with respect to the 5-ht containing enterochromaffin cells. Their number in duodenal biopsies was assessed by fluorescence histochemistry and they were examined by immunohistochemistry for peptides known or believed to occur in enterochromaffin cells. Antisera used were raised against substance P, motilin, and leu-enkephalin. In addition, the concentration of 5-HT was determined chemically. In adult coeliac disease there was a significant increase in the number of duodenal enterochromaffin cells compared with the control group. The concentration of 5-HT in the duodenal mucosa was also greatly increased. Substance P was found in a minority population of enterochromaffin cells. These cells were very few and did not increase in number in coeliac disease. Motilin cells were distinct from enterochromaffin cells. No enkephalin immunoreactive cells were found in the biopsies.

Citing Articles

Enteroendocrine cells regulate intestinal homeostasis and epithelial function.

Nwako J, McCauley H Mol Cell Endocrinol. 2024; 593:112339.

PMID: 39111616 PMC: 11401774. DOI: 10.1016/j.mce.2024.112339.

Hyperplastic proliferations of enteroendocrine cells.

Dayal Y Endocr Pathol. 2020; 5(1):4-26.

PMID: 32138418 DOI: 10.1007/BF02921366.

Impaired intestinal cholecystokinin secretion, a fascinating but overlooked link between coeliac disease and cholesterol gallstone disease.

Wang H, Liu M, Li X, Portincasa P, Wang D Eur J Clin Invest. 2017; 47(4):328-333.

PMID: 28186337 PMC: 8135131. DOI: 10.1111/eci.12734.

Lack of endogenous cholecystokinin promotes cholelithogenesis in mice.

Wang H, Liu M, Portincasa P, Tso P, Wang D Neurogastroenterol Motil. 2015; 28(3):364-75.

PMID: 26604077 PMC: 4760924. DOI: 10.1111/nmo.12734.

The relation between celiac disease, nonceliac gluten sensitivity and irritable bowel syndrome.

El-Salhy M, Hatlebakk J, Gilja O, Hausken T Nutr J. 2015; 14:92.

PMID: 26345589 PMC: 4561431. DOI: 10.1186/s12937-015-0080-6.

References

Hakanson R, Owman C, SJOBERG N, Sporrong B . Amine mechanisms in enterochromaffin and enterochromaffin-like cells of gastric mucosa in various mammals. Histochemie. 1970; 21(3):189-220. DOI: 10.1007/BF00304213. View

Challacombe D, Brown G, Black S, Storrie M . Increased excretion of 5-hydroxyindoleacetic acid in urine of children with untreated coeliac disease. Arch Dis Child. 1972; 47(253):442-5. PMC: 1648119. DOI: 10.1136/adc.47.253.442. View

Pearse A, Polak J, Bloom S, Adams C, Dryburgh J, Brown J . Enterochromaffin cells of the mammalian small intestine as the source of motilin. Virchows Arch B Cell Pathol. 1974; 16(2):111-20. DOI: 10.1007/BF02894069. View

Polak J, Pearse A, Heath C . Complete identification of endocrine cells in the gastrointestinal tract using semithin-thin sections to identify motilin cells in human and animal intestine. Gut. 1975; 16(3):225-9. PMC: 1410960. DOI: 10.1136/gut.16.3.225. View

Pearse A, Polak J . Immunocytochemical localization of substance P in mammalian intestine. Histochemistry. 1975; 41(4):373-5. DOI: 10.1007/BF00490081. View

Nilsson G, Larsson L, Hakanson R, Brodin E, PERNOW B, Sundler F . Localization of substance P-like immunoreactivity in mouse gut. Histochemistry. 1975; 43(1):97-9. DOI: 10.1007/BF00490158. View

Nilsson G, PERNOW B, FISCHER G, Folkers K . Presence of substance P-like immunoreactivity in plasma from man and dog. Acta Physiol Scand. 1975; 94(4):542-4. DOI: 10.1111/j.1748-1716.1975.tb05915.x. View

Heitz P, Polak J, Timson D, Pearse A . Enterochromaffin cells as the endocrine source of gastrointestinal substance P. Histochemistry. 1976; 49(4):343-7. DOI: 10.1007/BF00496138. View

Pearse A . The cellular origin of motilin in the gastrointestinal tract. Scand J Gastroenterol Suppl. 1976; 39:35-8. View

10.

Polak J, Heitz P, Pearse A . Differential localisation of substance P and motilin. Scand J Gastroenterol Suppl. 1976; 39:39-42. View

11.

Forssmann W, Yanaihara N, Helmstaedter V, GRUBE D . Differential demonstration of the motilin-cell and the enterochromaffin-cell. Scand J Gastroenterol Suppl. 1976; 39:43-5. View

12.

Challacombe D, Robertson K . Enterochromaffin cells in the duodenal mucosa of children with coeliac disease. Gut. 1977; 18(5):373-6. PMC: 1411490. DOI: 10.1136/gut.18.5.373. View

13.

Alumets J, Hakanson R, Ingemansson S, Sundler F . Substance P and 5-HT in granules isolated from an intestinal argentaffin carcinoid. Histochemistry. 1977; 52(3):217-22. DOI: 10.1007/BF00495858. View

14.

Miller R, Chang K, Cooper B, Cuatrecasas P . Radioimmunoassay and characterization of enkephalins in rat tissues. J Biol Chem. 1978; 253(2):531-8. View

15.

Maickel R, Cox Jr R, Saillant J, Miller F . A method for the determination of serotonin and norepinephrine in discrete areas of rat brain. Int J Neuropharmacol. 1968; 7(3):275-81. DOI: 10.1016/0028-3908(68)90034-8. View

16.

Heitz P, Kasper M, Krey G, Polak J, Pearse A . Immunoelectron cytochemical localization of motilin in human duodenal enterochromaffin cells. Gastroenterology. 1978; 74(4):713-7. View

17.

Sundler F, Alumets J, Hakanson R . 5-Hydroxytryptamine-containing enterochromaffin cells: storage site of substance P. Acta Physiol Scand Suppl. 1977; 452:121-3. View

18.

Sundler F, Alumets J, Hakanson R, Sjolund K, Yanaihara N . Motilin and carcinoid tumours. Lancet. 1978; 1(8073):1101. DOI: 10.1016/s0140-6736(78)90947-9. View

19.

Polak J, Buchan A, Dryburch J, Christofides H, Bloom S, Yanaihara N . Immunoreactive motilins?. Lancet. 1978; 1(8078):1364-5. DOI: 10.1016/s0140-6736(78)92440-6. View

20.

Alumets J, Hakanson R, Sundler F, Chang K . Leu-enkephalin-like material in nerves and enterochromaffin cells in the gut. An immunohistochemical study. Histochemistry. 1978; 56(3-4):187-96. DOI: 10.1007/BF00495979. View