Alpha 2.0
Login Register
» Articles » PMID: 1095530

Immunocytochemical Localization of Substance P in Mammalian Intestine

Overview
Journal Histochemistry
Specialty Biochemistry
Date 1975 Jan 1
PMID 1095530
Citations 81
Authors
A G Pearse
J M Polak
Affiliations
Soon will be listed here.
Abstract

In mammalian intestine immunoreactive Substance P is localized not only in the plexuses of Auerbach and Meissner, as could be anticipated, but also in a number of basally situated, often basigranular, endocrine cells which have been identified tentatively as enterochromaffin. The presence of a neurohormone in cells of this type confirms their close association with the nervous system, noted by Masson (1924), and suggests that their postulated origin from the nervous system (Danisch, 1924) may well be correct.

Citing Articles

Topographical distribution and morphology of SP-IR axons in the antrum, pylorus, and duodenum of mice.

Mistareehi A, Bendowski K, Bizanti A, Madas J, Zhang Y, Kwiat A Auton Neurosci. 2023; 246:103074.

PMID: 36804650 PMC: 10515648. DOI: 10.1016/j.autneu.2023.103074.

A Focus on Enterochromaffin Cells among the Enteroendocrine Cells: Localization, Morphology, and Role.

Rezzani R, Franco C, Franceschetti L, Giano M, Favero G Int J Mol Sci. 2022; 23(7).

PMID: 35409109 PMC: 8998884. DOI: 10.3390/ijms23073758.

Glucagon-like peptide 1 and glucose-dependent insulinotropic polypeptide stimulate release of substance P from TRPV1- and TRPA1-expressing sensory nerves.

Mayer F, Gunawan A, Tso P, Aponte G Am J Physiol Gastrointest Liver Physiol. 2020; 319(1):G23-G35.

PMID: 32421358 PMC: 7468754. DOI: 10.1152/ajpgi.00189.2019.

Gut endocrine and neural peptides.

Bishop A, Polak J Endocr Pathol. 2020; 1(1):4-24.

PMID: 32138398 DOI: 10.1007/BF02915151.

Circulating immunoreactive substance P in man.

Skrabanek P, Cannon D, Kirrane J, Legge D, Powell D Ir J Med Sci. 2016; 145(1):399.

PMID: 27517263 DOI: 10.1007/BF02938979.

References
1.
Chang M, Leeman S, Niall H . Amino-acid sequence of substance P. Nat New Biol. 1971; 232(29):86-7. DOI: 10.1038/newbio232086a0. View
2.
EULER U, Gaddum J . An unidentified depressor substance in certain tissue extracts. J Physiol. 1931; 72(1):74-87. PMC: 1403098. DOI: 10.1113/jphysiol.1931.sp002763. View
3.
Lembeck F . [Central transmission of afferent impulses. III. Incidence and significance of the substance P in the dorsal roots of the spinal cord]. Naunyn Schmiedebergs Arch Exp Pathol Pharmakol. 1953; 219(3):197-213. View
4.
Pearse A, Polak J, Adams C, Kendall P . Diethylpyrocarbonate, a vapour-phase fixative for immunofluorescence studies on polypeptide hormones. Histochem J. 1974; 6(3):347-52. DOI: 10.1007/BF01312253. View
5.
Goodfriend T, Levine L, Fasman G . ANTIBODIES TO BRADYKININ AND ANGIOTENSIN: A USE OF CARBODIIMIDES IN IMMUNOLOGY. Science. 1964; 144(3624):1344-6. DOI: 10.1126/science.144.3624.1344. View