» Articles » PMID: 705336

Prenatal Exposure to Prednisone in Humans and Animals Retards Intrauterine Growth

Overview
Journal Science
Specialty Science
Date 1978 Oct 27
PMID 705336
Citations 89
Authors
Affiliations
Soon will be listed here.
Abstract

Prednisone treatment for infertility and subsequent pregnancy maintenance in humans resulted in a significant decrease in the birth weight of full-term infants and a marked increase in the percentage of newborn infants weighing 2500 grams or less, that is, "light for dates" in comparison to control offspring. A parallel experiment with mice indicated that the reduction of birth weight was caused by exposure to corticosteroids rather than to maternal disease or malfunction.

Citing Articles

Insights into neuromyelitis optica spectrum disorder and pregnancy from a single-center study in Thailand.

Budtarad N, Ongphichetmehta T, Siritho S Sci Rep. 2025; 15(1):4011.

PMID: 39893222 PMC: 11787356. DOI: 10.1038/s41598-025-88624-x.


Effect of hydroxychloroquine on pregnancy outcome in patients with SLE: a systematic review and meta-analysis.

Zhu Q, Wang J, Sun Q, Xie Z, Li R, Yang Z Lupus Sci Med. 2024; 11(2).

PMID: 39477333 PMC: 11529578. DOI: 10.1136/lupus-2024-001239.


Evaluation of the Effect of Early-Onset Steroid Treatment in the COVID-19-Positive Pregnant Women on Pregnancy Outcomes.

Elgormus N, Senyigit A, Okuyan O, Bozkurt F, Aydin D, Uzun H Viruses. 2024; 16(9).

PMID: 39339929 PMC: 11437463. DOI: 10.3390/v16091453.


Activation of the PGC-1α-mediated mitochondrial glutamine metabolism pathway attenuates female offspring osteoarthritis induced by prenatal excessive prednisone.

Li Q, Zhang F, Dai Y, Liu L, Chen L, Wang H Sci China Life Sci. 2024; 67(11):2382-2397.

PMID: 39180608 DOI: 10.1007/s11427-023-2593-4.


Neurodevelopment Is Dependent on Maternal Diet: Placenta and Brain Glucose Transporters GLUT1 and GLUT3.

Daida T, Shin B, Cepeda C, Devaskar S Nutrients. 2024; 16(14).

PMID: 39064806 PMC: 11279700. DOI: 10.3390/nu16142363.