Effects of Prostacyclin (PGI2) and Adenosine (ASN) on Total and Regional Blood Flow of Isolated, Collateralized Dog Hearts

Overview

Journal Basic Res Cardiol

Specialty Cardiology & Vascular Diseases

Date 1981 May 1

PMID 7023464

Citations 1

Authors

J SCHOLTHOLT

H Birringer

V B Fiedler

B Scholkens

Affiliations

Soon will be listed here.

Abstract

Dogs were subjected to chronic occlusion of the left circumflex and the right coronary artery by ameroid-type constrictors 4-5 weeks before the experiments. The hearts were isolated, fibrillated and perfused with blood (100 mm Hg) from a support dog. Total and regional myocardial blood flow as well as peripheral coronary pressure (circumflex artery) were determined before and during infusion of PGI2 and ASN into the isolated hearts. Both drugs increased total and regional blood flow to all parts of the myocardium in a dose-dependent manner, PGI2 being 2-3 times more potent than ASN. The perfusion pressure for the collateral-dependent myocardium, the peripheral coronary pressure, decreased following high doses of both drugs. For PGI2 a dose level existed where total flow was increased, while peripheral coronary pressure remained unaffected. After termination of the infusion of PGI2, a peripheral coronary pressure rose above predrug level with the total blood flow still being elevated. These findings indicate a PGI2-induced dilatation of collateral vessels. In general, the hemodynamic profile within the isolated hearts and the support dogs was characterized by the pronounced vasodilatory effects of PGI2 on arterioles. However, these effects did not deteriorate further the non-homogenous blood flow distribution in the collateralized portions of the myocardium.

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References

Link H, Rosen R, Schror K . Prostacyclin: a potent coronary dilating agent in the rat isolated heart [proceedings]. J Physiol. 1978; 284:106P-107P. View

HYMAN A, Kadowitz P, Lands W, Crawford C, Fried J, Barton J . Coronary vasodilator activity of 13,14-dehydroprostacyclin methyl ester: comparison with prostacyclin and other prostanoids. Proc Natl Acad Sci U S A. 1978; 75(7):3522-6. PMC: 392810. DOI: 10.1073/pnas.75.7.3522. View

Chapple D, Dusting G, Hughes R, Vane J . Some direct and reflex cardiovascular actions of prostacyclin (PGI2) and prostaglandin E2 in anaesthetized dogs. Br J Pharmacol. 1980; 68(3):437-47. PMC: 2044201. DOI: 10.1111/j.1476-5381.1980.tb14557.x. View

Dusting G, Moncada S, Vane J . Prostacyclin (PGX) is the endogenous metabolite responsible for relaxation of coronary arteries induced by arachindonic acid. Prostaglandins. 1977; 13(1):3-15. DOI: 10.1016/0090-6980(77)90037-5. View

MILLER O, Aiken J, Hemker D, Shebuski R, Gorman R . Prostacyclin stimulation of dog arterial cyclic AMP levels. Prostaglandins. 1979; 18(6):915-25. DOI: 10.1016/0090-6980(79)90128-x. View

Ito T, Ogawa K, Enomoto I, Hashimoto H, Kai I, Satake T . Comparison of the effects of PGI2 and PGE1 on coronary and systemic hemodynamics and coronary arterial cyclic nucleotide levels in dogs. Adv Prostaglandin Thromboxane Res. 1980; 7:641-6. View

Lefer A, Ogletree M, Smith J, Silver M, Nicolaou K, Barnette W . Prostacyclin: a potentially valuable agent for preserving myocardial tissue in acute myocardial ischemia. Science. 1978; 200(4337):52-4. DOI: 10.1126/science.345441. View

Schror K, Rosen R, Link H, Rosen P . Physiological and biochemical parameters of prostacyclin action on the heart and the coronary vasculature. Adv Prostaglandin Thromboxane Res. 1980; 7:625-30. View

Wennmalm A . Prostacyclin-dependent coronary vasodilation in rabbit and guinea pig hearts. Acta Physiol Scand. 1979; 106(1):47-52. DOI: 10.1111/j.1748-1716.1979.tb06368.x. View

10.

Ogletree M, Lefer A, Smith J, Nicolaou K . Studies on the protective effect of prostacyclin in acute myocardial ischemia. Eur J Pharmacol. 1979; 56(1-2):95-103. DOI: 10.1016/0014-2999(79)90438-2. View

11.

Schror K, Rosen P . Prostacyclin (PGI2) decreases the cyclic AMP level in coronary arteries. Naunyn Schmiedebergs Arch Pharmacol. 1979; 306(1):101-3. DOI: 10.1007/BF00515602. View

12.

De Deckere E, Nugteren D, Ten Hoor F . Prostacyclin is the major prostaglandin released from the isolated perfused rabbit and rat heart. Nature. 1977; 268(5616):160-3. DOI: 10.1038/268160a0. View

13.

Szczeklik A, Gryglewski R, Nizankowski R, Musial J, Pieton R, MRUK J . Circulatory and anti-platelet effects of intravenous prostacyclin in healthy men. Pharmacol Res Commun. 1978; 10(6):545-56. DOI: 10.1016/s0031-6989(78)80053-8. View

14.

Dembinska-Kiec A, Rucker W, Schonhofer P . Effects of PGI2 and PGI analogues on cAMP levels in cultured endothelial and smooth muscle cells derived from bovine arteries. Naunyn Schmiedebergs Arch Pharmacol. 1980; 311(1):67-70. DOI: 10.1007/BF00500304. View

15.

Fitzpatrick T, Alter I, Corey E, RAMWELL P, Rose J, Kot P . Cardiovascular responses to PGI2 (prostacyclin) in the dog. Circ Res. 1978; 42(2):192-4. DOI: 10.1161/01.res.42.2.192. View

16.

NEEDLEMAN P, BRONSON S, Wyche A, Sivakoff M, Nicolaou K . Cardiac and renal prostaglandin I2. Biosynthesis and biological effects in isolated perfused rabbit tissues. J Clin Invest. 1978; 61(3):839-49. PMC: 372599. DOI: 10.1172/JCI108998. View

17.

Waldman H, Alter I, Kot P, Rose J, RAMWELL P . Effect of lung transit on systemic depressor responses to arachidonic acid and prostacyclin in dogs. J Pharmacol Exp Ther. 1978; 204(2):289-93. View

18.

Hintze T, Martin E, Messina E, Kaley G . Prostacyclin (PGI2) elicits reflex bradycardia in dogs: evidence for vagal mediation. Proc Soc Exp Biol Med. 1979; 162(1):96-100. DOI: 10.3181/00379727-162-40625. View

19.

Gryglewski R, Bunting S, Moncada S, Flower R, Vane J . Arterial walls are protected against deposition of platelet thrombi by a substance (prostaglandin X) which they make from prostaglandin endoperoxides. Prostaglandins. 1976; 12(5):685-713. DOI: 10.1016/0090-6980(76)90047-2. View

20.

Kirstein A . Cardiac prostacyclin release: stimulation by hypoxia and various agents. Scand J Haematol Suppl. 1979; 34:105-11. DOI: 10.1111/j.1600-0609.1979.tb01580.x. View