Epidermal Growth Factor Inhibits Cytoskeleton-related Changes in the Surface of Parietal Cells

Overview

Journal J Cell Biol

Specialty Cell Biology

Date 1981 Jan 1

PMID 7009622

Citations 11

Authors

A Gonzalez

J Garrido

J D Vial

Affiliations

Soon will be listed here.

Abstract

The effect of epidermal growth factor (EGF) on gastric acid secretion was correlated with the morphological changes of the apical pole of rat parietal cells studied by transmission electron microscopy. Gastric acid secretion was stimulated by histamine, carbachol, pentagastrin, and insulin-induced hypoglycemia, and estimated by continuous recording of pH variations of gastric luminal perfusate. EGF inhibits acid secretion in these conditions. The action of the hormone also results in the arrest or reversal of the changes in shape undergone by parietal cells as they go into secretion. In view of the evidence involving cytoskeletal elements in the generation of these structural alterations, our observations suggest that the action of EGF on gastric acid secretion may be a consequence of a general effect of this hormone on cytoskeletal function.

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