The Role of Calcium in the Ischemic Myocardium

Overview

Journal Am J Pathol

Publisher Elsevier

Specialty Pathology

Date 1981 Feb 1

PMID 7008622

Citations 57

Authors

W G NAYLER

Affiliations

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Abstract

Ischemia of the myocardium results in a loss of ultrastructure and function. Tension generation is diminished or abolished, electrolyte imbalance occurs, and the ATP-generating capacity of the mitochondria is reduced. An intracellular accumulation of Ca2+ appears to precipitate many of these changes, the intracellular accumulation of Ca2+ being caused, in turn, by a failure of the ATP-dependent mechanisms responsible for maintaining intracellular homeostasis with respect to Ca2+. This hypothesis has been tested by the use of hypothermia, pretreatment with verapamil and a reduced extracellular Ca2+ to modify the events precipitated by an ischemic episode.

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References

Jennings R, GANOTE C, Reimer K . Ischemic tissue injury. Am J Pathol. 1975; 81(1):179-98. PMC: 2032306. View

NAYLER W, Fassold E, Yepez C . Pharmacological protection of mitochondrial function in hypoxic heart muscle: Effect of verapamil, propranolol, and methylprednisolone. Cardiovasc Res. 1978; 12(3):152-61. DOI: 10.1093/cvr/12.3.152. View

SORDAHL L, McCollum W, Wood W, Schwartz A . Mitochondria and sarcoplasmic reticulum function in cardiac hypertrophy and failure. Am J Physiol. 1973; 224(3):497-502. DOI: 10.1152/ajplegacy.1973.224.3.497. View

Jennings R, Sommers H, KALTENBACH J, West J . ELECTROLYTE ALTERATIONS IN ACUTE MYOCARDIAL ISCHEMIC INJURY. Circ Res. 1964; 14:260-9. DOI: 10.1161/01.res.14.3.260. View

El-Sherif N, LAZZARA R . Reentrant ventricular arrhythmias in the late myocardial infarction period. 7. Effect of verapamil and D-600 and the role of the "slow channel". Circulation. 1979; 60(3):605-15. DOI: 10.1161/01.cir.60.3.605. View

BRADLEY L, Jacob M, Jacobs E, SANADI D . Uncoupling of oxidative phosphorylation by cadmium ion. J Biol Chem. 1956; 223(1):147-56. View

NAYLER W, Yepez C, Fassold E, Ferrari R . Prolonged protective effect of propranolol on hypoxic heart muscle. Am J Cardiol. 1978; 42(2):217-25. DOI: 10.1016/0002-9149(78)90903-7. View

ZIMMERMAN A, Hulsmann W . Paradoxical influence of calcium ions on the permeability of the cell membranes of the isolated rat heart. Nature. 1966; 211(5049):646-7. DOI: 10.1038/211646a0. View

Hearse D, Humphrey S, NAYLER W, Slade A, Border D . Ultrastructural damage associated with reoxygenation of the anoxic myocardium. J Mol Cell Cardiol. 1975; 7(5):315-24. DOI: 10.1016/0022-2828(75)90121-2. View

10.

Clark R, FERGUSON T, West P, Shuchleib R, Henry P . Pharmacological preservation of the ischemic heart. Ann Thorac Surg. 1977; 24(4):307-14. DOI: 10.1016/s0003-4975(10)63405-4. View

11.

NAYLER W, Ferrari R, Williams A . Protective effect of pretreatment with verapamil, nifedipine and propranolol on mitochondrial function in the ischemic and reperfused myocardium. Am J Cardiol. 1980; 46(2):242-8. DOI: 10.1016/0002-9149(80)90064-8. View

12.

Hearse D . Oxygen deprivation and early myocardial contractile failure: a reassessment of the possible role of adenosine triphosphate. Am J Cardiol. 1979; 44(6):1115-21. DOI: 10.1016/0002-9149(79)90177-2. View

13.

Shine K, DOUGLAS A, RICCHIUTI N . Ischemia in isolated interventricular septa: mechanical events. Am J Physiol. 1976; 231(4):1225-32. DOI: 10.1152/ajplegacy.1976.231.4.1225. View

14.

Katz A, Reuter H . Cellular calcium and cardiac cell death. Am J Cardiol. 1979; 44(1):188-90. DOI: 10.1016/0002-9149(79)90270-4. View

15.

Kahles H, Goring G, Nordbeck H, Preusse C, Spieckermann P . Functional behaviour of isolated heart muscle mitochondria after in situ ischemia. Polarographic analysis of mitochondrial oxidative phosphorylation. Basic Res Cardiol. 1977; 72(6):563-74. DOI: 10.1007/BF01907037. View

16.

Shen A, Jennings R . Kinetics of calcium accumulation in acute myocardial ischemic injury. Am J Pathol. 1972; 67(3):441-52. PMC: 2032736. View

17.

NAYLER W, Yepez C, Poole-Wilson P . The effect of beta-adrenoceptor and Ca2+ antagonist drugs on the hypoxia-induced increased in resting tension. Cardiovasc Res. 1978; 12(11):666-74. DOI: 10.1093/cvr/12.11.666. View

18.

Tomlinson C, Dhalla N . Excitation-contraction coupling in heart. IX. Changes in the intracellular stores of calcium in failing hearts due to lack of substrate and oxygen. Cardiovasc Res. 1973; 7(4):470-6. DOI: 10.1093/cvr/7.4.470. View

19.

Peng C, KANE J, Murphy M, Straub K . Abnormal mitochondrial oxidative phosphorylation of ischemic myocardium reversed by Ca2+-chelating agents. J Mol Cell Cardiol. 1977; 9(11):897-908. DOI: 10.1016/s0022-2828(77)80010-2. View

20.

Opie L, MANSFORD K, Owen P . Effects of increased heart work on glycolysis and adenine nucleotides in the perfused heart of normal and diabetic rats. Biochem J. 1971; 124(3):475-90. PMC: 1177216. DOI: 10.1042/bj1240475. View