The Role of Cardiolipin Concentration and Acyl Chain Composition on Mitochondrial Inner Membrane Molecular Organization and Function

Overview

Journal Biochim Biophys Acta Mol Cell Biol Lipids

Publisher Elsevier

Specialties Biochemistry
Biophysics
Cell Biology

Date 2019 Apr 6

PMID 30951877

Citations 43

Authors

Edward Ross Pennington

Katsuhiko Funai

David A Brown

Saame Raza Shaikh

Affiliations

Soon will be listed here.

Abstract

Cardiolipin (CL) is a key phospholipid of the mitochondria. A loss of CL content and remodeling of CL's acyl chains is observed in several pathologies. Strong shifts in CL concentration and acyl chain composition would presumably disrupt mitochondrial inner membrane biophysical organization. However, it remains unclear in the literature as to which is the key regulator of mitochondrial membrane biophysical properties. We review the literature to discriminate the effects of CL concentration and acyl chain composition on mitochondrial membrane organization. A widely applicable theme emerges across several pathologies, including cardiovascular diseases, diabetes, Barth syndrome, and neurodegenerative ailments. The loss of CL, often accompanied by increased levels of lyso-CLs, impairs mitochondrial inner membrane organization. Modest remodeling of CL acyl chains is not a major driver of impairments and only in cases of extreme remodeling is there an influence on membrane properties.

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