Gardner's Syndrome. Recent Developments in Research and Management

Overview

Journal Dig Dis Sci

Specialty Gastroenterology

Date 1980 Dec 1

PMID 7004810

Citations 13

Authors

E W Naylor

E Lebenthal

Affiliations

Soon will be listed here.

Abstract

In recent years, a number of comprehensive reviews have been written on inherited intestinal polyposis syndromes (1-7), but none has dealt specifically with Gardner's syndrome and none has focused on basic research being carried out in an attempt to understand this syndrome and to improve the medical management of affected patients. A better understanding of this rare genetic disorder is essential for surgeons, gastroenterologists, cancer researchers, and geneticists alike. To the clinician, it poses difficult challenges in management; to the cancer researcher, it presents a rare opportunity to study very early premalignant transformations; and to the geneticist, it poses exciting questions at the cellular, chromosomal, and molecular levels.

Citing Articles

Colorectal Carcinoma, Cyclooxygenases, and COX Inhibitors.

Ganduri V, Rajasekaran K, Duraiyarasan S, Adefuye M, Manjunatha N Cureus. 2022; 14(8):e28579.

PMID: 36185863 PMC: 9521169. DOI: 10.7759/cureus.28579.

A case of pneumatosis cystoides intestinalis mimicking familial adenomatous polyposis.

Ponz de Leon M, Bertarelli C, Casadei G, Grilli A, Bacchini P, Pedroni M Fam Cancer. 2012; 12(3):573-6.

PMID: 23196630 DOI: 10.1007/s10689-012-9587-6.

In search of adrenocortical stem and progenitor cells.

Kim A, Barlaskar F, Heaton J, Else T, Kelly V, Krill K Endocr Rev. 2009; 30(3):241-63.

PMID: 19403887 PMC: 2726842. DOI: 10.1210/er.2008-0039.

Endoscopic removal of the duodenal polyp in a patient with Gardner's syndrome.

Sweeney B, Anderson D Dig Dis Sci. 1982; 27(6):557-60.

PMID: 7083991 DOI: 10.1007/BF01296738.

Upper gastrointestinal tract polyps in familial adenomatosis coli.

Jarvinen H, Nyberg M, PELTOKALLIO P Gut. 1983; 24(4):333-9.

PMID: 6832628 PMC: 1419962. DOI: 10.1136/gut.24.4.333.

References

Keshgegian A, ENTERLINE H . Gardner's syndrome with duodenal adenomas, gastric adenomyoma and thyroid papillary--follicular adenocarcinoma. Dis Colon Rectum. 1978; 21(4):255-60. DOI: 10.1007/BF02586699. View

Utsunomiya J, Maki T, Iwama T, Matsunaga Y, Ichikawa T . Gastric lesion of familial polyposis coli. Cancer. 1974; 34(3):745-54. DOI: 10.1002/1097-0142(197409)34:3<745::aid-cncr2820340333>3.0.co;2-y. View

Dorazio R, Whelan Jr T . Lymphoid hyperplasia of the terminal ileum associated with familial polyposis coli. Ann Surg. 1970; 171(2):300-2. PMC: 1396661. DOI: 10.1097/00000658-197002000-00020. View

Danes B, KRUSH A, GARDNER E . Is Gardner syndrome a distinct genetic disorder?. Lancet. 1977; 2(8044):925. DOI: 10.1016/s0140-6736(77)90853-4. View

MacDonald J, Davis W, Crago H, Berk A . Gardner's syndrome and periampullary malignancy. Am J Surg. 1967; 113(3):425-30. DOI: 10.1016/0002-9610(67)90294-2. View

INGRAM I, Davis W . Primary carcinoma of the jejunum; a report of three cases and review of the literature. Am J Surg. 1954; 87(5):747-53. DOI: 10.1016/0002-9610(54)90174-9. View

McCONNELL T, PARSONS Jr L . Chromosome evaluation in familial polyposis of the colon. Rocky Mt Med J. 1968; 65(9):51-3. View

Louw J . Polypoid lesions of the large bowel in children with particular reference to benign lymphoid polyposis. J Pediatr Surg. 1968; 3(2):195-209. DOI: 10.1016/0022-3468(68)90001-8. View

Danes B . Increased tetraploidy: cell-specific for the Gardner gene in the cultured cell. Cancer. 1976; 38(5):1983-8. DOI: 10.1002/1097-0142(197611)38:5<1983::aid-cncr2820380520>3.0.co;2-i. View

10.

MCCAUGHAN Jr J, SODER P, Biddle L . Gardner's syndrome: report of two unrelated cases and discussion of management of the disease. Dis Colon Rectum. 1966; 9(4):286-92. DOI: 10.1007/BF02616926. View

11.

YAFFEE H . GASTRIC POLYPOSIS AND SOFT TISSUE TUMORS. A VARIANT OF GARDNER'S SYNDROME. Arch Dermatol. 1964; 89:806-8. DOI: 10.1001/archderm.1964.01590300034011. View

12.

Kaplan B . Gardner's syndrome: heredofamilial adenomatosis associated with "soft and hard" fibrous tumors and epidermoid cysts. Dis Colon Rectum. 1961; 4:252-62. DOI: 10.1007/BF02616601. View

13.

SACHATELLO C . Familial polyposis of the colon. I. Leukocytic chromosome determinations--report of a patient with familial polyposis of the colon and Klinefelter's syndrome. Dis Colon Rectum. 1970; 13(5):368-71. DOI: 10.1007/BF02616757. View

14.

Hunt R, MORGAN H, ACKERMAN L . Principles in the management of extra-abdominal desmoids. Cancer. 1960; 13:825-36. DOI: 10.1002/1097-0142(196007/08)13:4<825::aid-cncr2820130427>3.0.co;2-e. View

15.

MOERTEL C, Hill J, ADSON M . Surgical management of multiple polyposis. The problem of cancer in the retained bowel segment. Arch Surg. 1970; 100(4):521-6. DOI: 10.1001/archsurg.1970.01340220197033. View

16.

BOLEY S, MCKINNON W, MARZULLI V . The management of familial gastrointestinal polyposis involving stomach and colon. Surgery. 1961; 50:691-6. View

17.

Smith W . Multiple polyposis, Gardner's syndrome and desmoid tumors. Dis Colon Rectum. 1958; 1(5):323-32. DOI: 10.1007/BF02616659. View

18.

Bussey H . Gastrointestinal polyposis. Gut. 1970; 11(11):970-8. PMC: 1553130. DOI: 10.1136/gut.11.11.970. View

19.

SIMPSON R, HARRISON Jr E, MAYO C . MESENTERIC FIBROMATOSIS IN FAMILIAL POLYPOSIS. A VARIANT OF GARDNER'S SYNDROME. Cancer. 1964; 17:526-34. DOI: 10.1002/1097-0142(196404)17:4<526::aid-cncr2820170414>3.0.co;2-q. View

20.

HELLER E, LEWIS Jr H . Benign lymphoma of rectum. Am J Pathol. 1950; 26(3):463-71. PMC: 1942864. View