Cowden's Disease: a Case Report and Literature Review

Overview

Journal Gastrointest Radiol

Specialties Gastroenterology
Radiology

Date 1987 Jan 1

PMID 3040507

Citations 6

Authors

Y M Chen

D J Ott

W C Wu

D W Gelfand

Affiliations

Soon will be listed here.

Abstract

Cowden's disease, or multiple hamartoma syndrome, is an uncommon condition with characteristic mucocutaneous lesions associated with abnormalities of the breast, thyroid, and gastrointestinal tract. We describe a 51-year-old man with hyperplastic polyposis of the entire alimentary tract as the most prominent feature of this disease. We also present a review of 85 cases of this entity as reported in the English medical literature, and summarize the pertinent findings.

Citing Articles

Multiple hamartoma syndrome: clinicoradiological evaluation and histopathological correlation with brief review of literature.

Monga E, Gupta P, Munshi A, Agarwal S Indian J Dermatol. 2014; 59(6):598-601.

PMID: 25484393 PMC: 4248500. DOI: 10.4103/0019-5154.143535.

Colonic polyposis and neoplasia in Cowden syndrome.

Stanich P, Owens V, Sweetser S, Khambatta S, Smyrk T, Richardson R Mayo Clin Proc. 2011; 86(6):489-92.

PMID: 21628613 PMC: 3104908. DOI: 10.4065/mcp.2010.0816.

Multiple primary malignancies and subtle mucocutaneous lesions associated with a novel PTEN gene mutation in a patient with Cowden syndrome: case report.

Vasovcak P, Senkerikova M, Hatlova J, Krepelova A BMC Med Genet. 2011; 12:38.

PMID: 21406108 PMC: 3065398. DOI: 10.1186/1471-2350-12-38.

Frequent gastrointestinal polyps and colorectal adenocarcinomas in a prospective series of PTEN mutation carriers.

Heald B, Mester J, Rybicki L, Orloff M, Burke C, Eng C Gastroenterology. 2010; 139(6):1927-33.

PMID: 20600018 PMC: 3652614. DOI: 10.1053/j.gastro.2010.06.061.

Genetic testing for hereditary colorectal cancer.

Hampel H Surg Oncol Clin N Am. 2009; 18(4):687-703.

PMID: 19793575 PMC: 2821160. DOI: 10.1016/j.soc.2009.08.001.

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