UGA Suppressor That Maps Within a Cluster of Ribosomal Protein Genes

Overview

Journal J Bacteriol

Publisher American Society for Microbiology

Specialty Microbiology

Date 1980 Oct 1

PMID 6998953

Citations 6

Authors

H M Johnston

J R Roth

Affiliations

Soon will be listed here.

Abstract

A suppressor of UGA mutations (supU) maps near or within a cluster of ribosomal protein genes at 72 min on the Salmonella typhimurium genetic map. The suppressor is relatively inefficient, and its activity is abolished by rpsL (formerly strA) mutations. The suppressor is dominant to a wild-type supU allele. The map position of this suppressor suggests that it may owe its activity to an alteration of ribosome structure.

Citing Articles

Frameshift and wild-type proteins are often highly similar because the genetic code and genomes were optimized for frameshift tolerance.

Wang X, Dong Q, Chen G, Zhang J, Liu Y, Cai Y BMC Genomics. 2022; 23(1):416.

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Suppression of TGA mutations in the Bacillus subtilis spoIIR gene by prfB mutations.

Karow M, Rogers E, Lovett P, Piggot P J Bacteriol. 1998; 180(16):4166-70.

PMID: 9696765 PMC: 107413. DOI: 10.1128/JB.180.16.4166-4170.1998.

Linkage map of Salmonella typhimurium, Edition VI.

Sanderson K, Roth J Microbiol Rev. 1983; 47(3):410-53.

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Genetic characterization of the sufj frameshift suppressor in Salmonella typhimurium.

Bossi L, Kohno T, Roth J Genetics. 1983; 103(1):31-42.

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Transfer ribonucleic acid-mediated suppression of termination codons in Escherichia coli.

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PMID: 3054467 PMC: 373150. DOI: 10.1128/mr.52.3.354-374.1988.

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