Requirement for B-lymphocyte Alloantigen in the Production of Neutrophil Migration Inhibition Factor from T Lymphocytes (NIF-T)

Overview

Journal Immunology

Specialty Allergy & Immunology

Date 1980 Apr 1

PMID 6991400

Citations 1

Authors

R H Weisbart

R Billing

Affiliations

Soon will be listed here.

Abstract

Neutrophil migration inhibition factor from T lymphocytes (NIF-T) is produced in response to mitogens as the result of cellular interactions between T and B lymphocytes. The requirement for B-cell alloantigen in this interaction process was indicated by (1) collaboration between peripheral blood T cells with various B lymphoblast cell lines but not with non-B lymphoblast cells for NIF-T production, (2) inhibition of NIF-T production by treating collaborating B lymphoblasts with B-cell specific antiserum, and (3) inhibition of NIF-T production by peripheral blood lypmphocytes in the presence of anti-B-cell antiserum and F(ab')2 with anti-B-cell specificity.

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