The Binding of Rabbit Basophil-derived Platelet-activating Factor to Rabbit Platelets

Overview

Journal Am J Pathol

Publisher Elsevier

Specialty Pathology

Date 1980 Mar 1

PMID 6987890

Citations 8

Authors

J O Shaw

P M Henson

Affiliations

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Abstract

The platelet binding characteristics of platelet-activating factor (PAF), a basophil-derived lipid that causes aggregation and secretion in rabbit platelets, were studied. In an assay in which binding was quantitated by loss of PAF activity, suspensions of washed rabbit platelets rapidly removed PAF from solution. Rabbit erythrocytes, lymphocytes, and neutrophils also bound PAF, but their binding capacity was less than that of the platelets. PAF binding to rabbit platelets was saturable and dependent on temperature and concentration of PAF and platelets but not on the presence of extracellular Ca2+. Initial rates of PAF binding and platelet secretion were identical, although temperature dependence studies suggested that binding was not the rate-controlling step in PAF-induced platelet secretion. Analysis of binding kinetics suggested that a PAF concentrations saturable for platelet secretion, only some of the available platelet binding sites were occupied.

Citing Articles

Proceedings of the British Pharmacological Society 8th-10th September, 1982. Abstracts.

Br J Pharmacol. 1982; 77 Suppl:445P-597P.

PMID: 7150878 PMC: 2044581.

Neutropenia induced by platelet-activating factor (PAF-acether) released from neutrophils: the inhibitory effect of prostacyclin (PGI2).

Camussi G, Tetta C, Segoloni G, Chiara Deregibus M, Bussolino F Agents Actions. 1981; 11(6-7):550-3.

PMID: 7041569 DOI: 10.1007/BF01978735.

Specific binding by human polymorphonuclear leucocytes of the immunological mediator 1-O-hexadecyl/octadecyl-2-acetyl-sn-glycero-3-phosphorylcholine.

Valone F, Goetzl E Immunology. 1983; 48(1):141-9.

PMID: 6848449 PMC: 1454001.

Metabolism of platelet-activating factor by blood platelets and plasma.

Alam I, Smith J, Silver M Lipids. 1983; 18(8):534-8.

PMID: 6413803 DOI: 10.1007/BF02535393.

Biology and biochemistry of platelet-activating factor.

OFlaherty J, Wykle R Clin Rev Allergy. 1983; 1(3):353-67.

PMID: 6370406 DOI: 10.1007/BF02991226.

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