The Immunological Profile of Mycosis Fungoides

Overview

Journal Clin Exp Immunol

Publisher Oxford University Press

Specialty Allergy & Immunology

Date 1982 Nov 1

PMID 6983938

Citations 4

Authors

J R Jensen

K Thestrup-Pedersen

S Ahrons

H Zachariae

Affiliations

Soon will be listed here.

Abstract

The immune reactivity of 25 patients with mycosis fungoides was studied twice with a 6 month interval using a panel of T lymphocyte surface markers and functional tests. Patients with clinically inactive disease (stage I + II) had normal T lymphocyte biology. Patients with clinically active disease (stage II-IV) had T lymphopenia, alterations in T cell subpopulations (T gamma and T mu) and a reduced lymphocyte reactivity in vitro following mitogen (PHA, Con A, PWM) and antigen (PPD) stimulation. They also had a reduced secretion of immunoglobulin in vitro after PWM stimulation, apparently due to the alterations in their T lymphocyte subpopulations. The observed changes in the peripheral blood T lymphocyte population and the in vitro function of lymphocytes were not shared by lymphocytes from histologically affected lymph nodes. The natural killer cell activity in blood lymphocytes was found to be normal in all patients.

Citing Articles

Etretinate therapy and immune reactivity.

Jensen J, ElRamley M, Herlin T, Kragballe K, Thestrup-Pedersen K Arch Dermatol Res. 1983; 275(4):259-60.

PMID: 6625655 DOI: 10.1007/BF00416674.

Levy S, Tempe J, Caussade P, Aleksijevic A, Grosshans E, Mayer S Cancer Immunol Immunother. 1984; 18(2):138-40.

PMID: 6595055 PMC: 11039169. DOI: 10.1007/BF00205749.

Natural and concanavalin A-induced cytotoxic activity towards continuously growing B lymphocytes derived from patients with cutaneous T-cell lymphoma.

Jensen J, Kaltoft K, Bisballe S, Thestrup-Pedersen K Arch Dermatol Res. 1986; 279(1):12-5.

PMID: 3101618 DOI: 10.1007/BF00404351.

Normal peripheral-blood lymphocyte cAMP and cGMP resting levels in untreated patients with mycosis fungoides.

Aleksijevic A, Caussade P, Lang J, STOCLET J, Grosshans E, Mayer S Arch Dermatol Res. 1985; 277(2):143-5.

PMID: 2985008 DOI: 10.1007/BF00414114.

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