Immune Responses in Experimental Allergic Neuritis

Overview

Journal J Neurol Neurosurg Psychiatry

Publisher BMJ Publishing Group

Specialties Neurology
Neurosurgery
Psychiatry

Date 1981 Jul 1

PMID 6974764

Citations 9

Authors

R A Hughes

M Kadlubowski

I A Gray

S Leibowitz

Affiliations

Soon will be listed here.

Abstract

The antibody and cell mediated immune responses were investigated in inbred Lewis rats with experimental allergic neuritis (EAN) induced by either P2, a protein purified from the bovine cauda equina nerve roots, or whole bovine nerve root myelin. In the P2 immunised animals both antibodies to P2 detected by radioimmunoassay and cell-mediated immunity to P2 assayed by skin testing appeared before the onset of EAN and persisted during and after the disease. In the myelin immunised animals the antibody titres were lower and somewhat delayed and the skin tests became negative at the height of the disease. Complement-fixing antibodies to galactocerebroside, which have been implicated in the production of demyelination under some circumstances, could not be detected in the serum after immunisation with either P2 or myelin. EAN was transferred passively with lymph node cells from rats immunised with either P2 or myelin although anti-P2 antibodies could not be detected in the serum of recipients with EAN. The results favour a cell-mediated immune response to P2 as the most important pathogenetic mechanism in EAN induced wtih whole myelin in the rat.

Citing Articles

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Autoimmune responses in peripheral nerve.

Hartung H, Willison H, Jung S, Pette M, Toyka K, Giegerich G Springer Semin Immunopathol. 1996; 18(1):97-123.

PMID: 8984683 DOI: 10.1007/BF00792612.

Cellular mRNA expression of interferon-gamma, IL-4 and transforming growth factor-beta (TGF-beta) by rat mononuclear cells stimulated with peripheral nerve myelin antigens in experimental allergic neuritis.

Zhu J, Mix E, Olsson T, Link H Clin Exp Immunol. 1994; 98(2):306-12.

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Intraneural injection of lymphocytes in experimental allergic neuritis.

Gilbert J, Feasby T, Hahn A Acta Neuropathol. 1983; 61(1):61-4.

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Blood-nerve barrier studies in experimental allergic neuritis.

Hahn A, Feasby T, Gilbert J Acta Neuropathol. 1985; 68(2):101-9.

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References

LAMPERT P . Mechanism of demyelination in experimental allergic neuritis. Electron microscopic studies. Lab Invest. 1969; 20(2):127-38. View

Sheremata W, Colby S, KARKHANIS Y, Eylar E . Cellular hypersensitivity to basic myelin (P2) protein in the Guillain-Barré syndrome. Can J Neurol Sci. 1975; 2(2):87-90. DOI: 10.1017/s0317167100020059. View

Kadlubowski M, Hughes R . Identification of the neuritogen for experimental allergic neuritis. Nature. 1979; 277(5692):140-1. DOI: 10.1038/277140a0. View

Sarvas H, Milek D, Weise M, Carnow T, Fudenberg H, Brostoff S . Radioimmunoassay for the P2 protein of bovine peripheral nerve myelin. J Immunol. 1980; 124(2):557-64. View

Nyland H, Aarli J . Guillain-Barré syndrome: demonstration of antibodies to peripheral nerve tissue. Acta Neurol Scand. 1978; 58(1):35-43. DOI: 10.1111/j.1600-0404.1978.tb02857.x. View

Hughes R, Stedronska J . The susceptibility of rat strains to experimental allergic encephalomyelitis. Immunology. 1973; 24(5):879-84. PMC: 1422816. View

Saida T, Saida K, Dorfman S, Silberberg D, Sumner A, Manning M . Experimental allergic neuritis induced by sensitization with galactocerebroside. Science. 1979; 204(4397):1103-6. DOI: 10.1126/science.451555. View

Arnason B . Passive transfer of experimental allergic neuritis in Lewis rats by direct injection of sensitized lymphocytes into sciatic nerve. Acta Neuropathol. 1972; 22(1):1-6. DOI: 10.1007/BF00687545. View

Abramsky T, Teitelbaum D, Arnon R . Experimental allergic neuritis induced by a basic neuritogenic protein (P1L) of human peripheral nerve origin. Eur J Immunol. 1977; 7(4):213-7. DOI: 10.1002/eji.1830070405. View

10.

Kadlubowski M, Hughes R . The neuritogenicity and encephalitogenicity of P2 in the rat, guinea-pig and rabbit. J Neurol Sci. 1980; 48(2):171-8. DOI: 10.1016/0022-510x(80)90198-7. View

11.

Ortiz-Ortiz L, Weigle W . Cellular events in the induction of experimental allergic encephalomyelitis in rats. J Exp Med. 1976; 144(3):604-16. PMC: 2190418. DOI: 10.1084/jem.144.3.604. View

12.

Hughes R, Gray I, Stern M . Lymphocyte transformation in the presence of myelin basic protein in multiple sclerosis and control subjects. Acta Neurol Scand. 1979; 60(2):65-76. DOI: 10.1111/j.1600-0404.1979.tb02953.x. View

13.

Suzuki M, Kitamura K, Uyemura K, Ogawa Y, Ishihara Y, Matsuyama H . Neuritogenic activity of peripheral nerve myelin proteins in Lewis rats. Neurosci Lett. 1980; 19(3):353-8. DOI: 10.1016/0304-3940(80)90287-6. View

14.

HOFFMAN P, Powers J, Weise M, Brostoff S . Experimental allergic neuritis. I. Rat strain differences in the response to bovine myelin antigens. Brain Res. 1980; 195(2):355-62. DOI: 10.1016/0006-8993(80)90071-2. View

15.

Smith M, FORNO L, HOFMANN W . Experimental allergic neuritis in the Lewis rat. J Neuropathol Exp Neurol. 1979; 38(4):377-91. DOI: 10.1097/00005072-197907000-00003. View

16.

Shaw C, Alvord Jr E, KAKU J, KIES M . CORRELATION OF EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS WITH DELAYED-TYPE SKIN SENSITIVITY TO SPECIFIC HOMOLOGOUS ENCEPHALITOGEN. Ann N Y Acad Sci. 1965; 122:318-31. DOI: 10.1111/j.1749-6632.1965.tb20216.x. View

17.

Hahn A, Gilbert J, Feasby T . Passive transfer of demyelination by experimental allergic neuritis serum. Acta Neuropathol. 1980; 49(3):169-76. DOI: 10.1007/BF00707103. View

18.

Kadlubowski M, Hughes R, Gregson N . Experimental allergic neuritis in the Lewis rat: characterization of the activity of peripheral myelin and its major basic protein,P2. Brain Res. 1980; 184(2):439-54. DOI: 10.1016/0006-8993(80)90811-2. View

19.

ASTROM K, Waksman B . The passive transfer of experimental allergic encephalomyelitis and neuritis with living lymphoid cells. J Pathol Bacteriol. 1962; 83:89-106. DOI: 10.1002/path.1700830112. View