Three-dimensional Structure of a Pyridoxal-phosphate-dependent Enzyme, Mitochondrial Aspartate Aminotransferase

Overview

Journal Proc Natl Acad Sci U S A

Specialty Science

Date 1980 May 1

PMID 6930651

Citations 50

Authors

G C Ford

G Eichele

J N Jansonius

Affiliations

Soon will be listed here.

Abstract

X-ray diffraction studies to 2.8-A resolution have yielded the three-dimensional structure of mitochondrial aspartate aminotransferase (L-aspartate:2-oxoglutarate aminotransferase, EC 2.6.1.1), an isologous alpha 2 dimer (Mr = 2 x 45,000). The subunits are rich in secondary structure and contain two domains, one of which anchors the coenzyme, pyridoxal 5'-phosphate. Each active site lies between the subunits and is composed of residues from both of them.

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