Spinal Interneurone Depression by DS103-282

Overview

Journal Br J Pharmacol

Publisher Wiley

Specialty Pharmacology

Date 1983 May 1

PMID 6871557

Citations 6

Authors

D R Curtis

J D Leah

M J Peet

Affiliations

Soon will be listed here.

Abstract

The depressant effect of 5-chloro-4-(2-imidazolin-2-yl-amino)-2,1,3-benzothiodiazole (DS103-282) on the polysynaptic excitation of interneurones in the cat spinal cord appears to be related to a postsynaptic reduction in the effectiveness of excitatory transmitters than to interference with their presynaptic release.

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References

Davies J, Watkins J . Selective antagonism of amino acid-induced and synaptic excitation in the cat spinal cord. J Physiol. 1979; 297(0):621-35. PMC: 1458740. DOI: 10.1113/jphysiol.1979.sp013060. View

SAYERS A, Burki H, EICHENBERGER E . The pharmacology of 5-chloro-4-(2-imidazolin-2-yl-amino)-2,1,3-benzothiadiazole (DS 103-282), a novel myotonolytic agent. Arzneimittelforschung. 1980; 30(5):793-803. View

Davies J, Watkins J . Pharmacology of glutamate and aspartate antagonists on cat spinal neurones. Adv Biochem Psychopharmacol. 1981; 27:275-84. View

Curtis D, Lodge D, Bornstein J, Peet M . Selective effects of (-)-baclofen on spinal synaptic transmission in the cat. Exp Brain Res. 1981; 42(2):158-70. DOI: 10.1007/BF00236902. View

Davies J . Selective depression of synaptic transmission of spinal neurones in the cat by a new centrally acting muscle relaxant, 5-chloro-4-(2-imidazolin-2-yl-amino)-2, 1, 3-benzothiodazole (DS103-282). Br J Pharmacol. 1982; 76(3):473-81. PMC: 2071800. DOI: 10.1111/j.1476-5381.1982.tb09242.x. View