Article: Inheritance and expression of a sex-linked enzyme in the frog, Rana clamitans

The pattern of inheritance indicates that the gene for aconitase-1 is sex linked in the frog. Rana clamitans, and that the male is the heterogametic sex. Unlike mammals, both male and female frogs carry and express two alleles for this sex-linked gene. Therefore, the sex chromosomes in these frogs and probably others behave like an autosomal pair, with one homologue carrying a male-determining element.

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References

1.

Wright D, Richards C, NACE G . Inheritance of enzymes and blood proteins in the leopard frog, Rana pipiens: three linkage groups established. Biochem Genet. 1980; 18(5-6):591-616. DOI: 10.1007/BF00484404. View

2.

Baverstock P, Adams M, Polkinghorne R, Gelder M . A sex-linked enzyme in birds--Z-chromosome conservation but no dosage compensation. Nature. 1982; 296(5859):763-6. DOI: 10.1038/296763a0. View

3.

Elinson R . Genetic analysis of developmental arrest in an amphibian hybrid (Rana catesbeiana, Rana clamitans). Dev Biol. 1981; 81(1):167-76. DOI: 10.1016/0012-1606(81)90359-6. View

4.

Zaborski P . [Invariability of the H-Y antigen expression in the heterogametic sex of some amphbians and evidence for sexual dimophrism of the antigen expression in Pelodytes punctatus D (Amphibia, Anura)]. C R Seances Acad Sci D. 1979; 289(15):1153-6. View

5.

Iturra P, Veloso A . Evidence for heteromorphic sex chromosomes in male amphibians (Anura: Leptodactylidae). Cytogenet Cell Genet. 1981; 31(2):108-10. DOI: 10.1159/000131633. View

6.

Wright D, Richards C . Two sex-linked loci in the leopard frog, Rana pipiens. Genetics. 1983; 103(2):249-61. PMC: 1219977. DOI: 10.1093/genetics/103.2.249. View

7.

Wachtel S, Koo G, Boyse E . Evolutionary conservation of H-Y ('male') antigen. Nature. 1975; 254(5497):270-2. DOI: 10.1038/254270a0. View

8.

Mengden G . Linear differentiation of the C-band pattern of the W chromosome in snakes and birds. Chromosoma. 1981; 83(2):275-87. DOI: 10.1007/BF00286795. View

9.

Schmid M . Chromosome banding in amphibia. IV. Differentiation of GC- and AT-rich chromosome regions in Anura. Chromosoma. 1980; 77(1):83-103. DOI: 10.1007/BF00292043. View

10.

Mikamo K, WITSCHI E . Masculinization and breeding of the WW Xenopus. Experientia. 1964; 20(11):622-3. DOI: 10.1007/BF02144823. View

11.

Schempp W, Schmid M . Chromosome banding in Amphibia. VI. BrdU-replication patterns in anura and demonstration of XX/XY sex chromosomes in Rana esculenta. Chromosoma. 1981; 83(5):697-710. DOI: 10.1007/BF00328528. View

12.

Tymowska J . A comparative study of the karyotypes of eight Xenopus species and subspecies possessing a 36-chromosome complement. Cytogenet Cell Genet. 1977; 18(4):165-82. DOI: 10.1159/000130761. View

Inheritance and Expression of a Sex-linked Enzyme in the Frog, Rana Clamitans