Antifungal Activity in Human Urine and Serum After Ingestion of Garlic (Allium Sativum)

Overview

Journal Antimicrob Agents Chemother

Publisher American Society for Microbiology

Specialty Pharmacology

Date 1983 May 1

PMID 6870217

Citations 8

Authors

N Caporaso

S M Smith

R H Eng

Affiliations

Soon will be listed here.

Abstract

A fresh extract of garlic (Allium sativum) was administered orally to human volunteers. At intervals, serum and urine were collected and assayed for antifungal activity. The maximum tolerable dose was determined to be 25 ml of garlic extract. Larger amounts caused severe burning sensations in the esophagus and the stomach and vomiting. After oral ingestion of 25 ml of the extract, anticandidal and anticryptococcal activities were detected in undiluted serum 0.5 and 1 h after ingestion. No detectable antifungal activity was found in the excreted urine at any time after oral ingestion. Oral garlic is of limited value in the therapy of human fungal infections.

Citing Articles

Genotoxicity and 28-day repeated dose oral toxicity study of garlic essential oil in mice.

Lin Y, Lin M, Yeh T, Lai Y, Lu K, Huang H J Tradit Complement Med. 2022; 12(6):536-544.

PMID: 36325240 PMC: 9618392. DOI: 10.1016/j.jtcme.2022.05.001.

Allicin and Digestive System Cancers: From Chemical Structure to Its Therapeutic Opportunities.

Sarvizadeh M, Hasanpour O, Ghale-Noie Z, Mollazadeh S, Rezaei M, Pourghadamyari H Front Oncol. 2021; 11:650256.

PMID: 33987085 PMC: 8111078. DOI: 10.3389/fonc.2021.650256.

Identification of Essential Oils Including Garlic Oil and Black Pepper Oil with High Activity against .

Zhang Y, Bai C, Shi W, Alvarez-Manzo H, Zhang Y Pathogens. 2020; 9(6).

PMID: 32545549 PMC: 7350376. DOI: 10.3390/pathogens9060466.

improves antioxidant capacity of black garlic in the prevention of gestational diabetes mellitus: a randomized control trial.

Si L, Lin R, Jia Y, Jian W, Yu Q, Wang M Biosci Rep. 2019; 39(8).

PMID: 31362999 PMC: 6689107. DOI: 10.1042/BSR20182254.

Garlic compounds selectively kill childhood pre-B acute lymphoblastic leukemia cells in vitro without reducing T-cell function: Potential therapeutic use in the treatment of ALL.

Hodge G, Davis S, Rice M, Tapp H, Saxon B, Revesz T Biologics. 2009; 2(1):143-9.

PMID: 19707437 PMC: 2727784. DOI: 10.2147/btt.s2465.

References

Moore G, Atkins R . The fungicidal and fungistatic effects of an aqueous garlic extract on medically important yeast-like fungi. Mycologia. 1977; 69(2):341-8. View

Barone F, Tansey M . Isolation, purification, identification, synthesis, and kinetics of activity of the anticandidal component of Allium sativum, and a hypothesis for its mode of action. Mycologia. 1977; 69(4):793-825. View

Sharma V, Sethi M, Kumar A, Rarotra J . Antibacterial property of Allium sativum Linn.: in vivo & in vitro studies. Indian J Exp Biol. 1977; 15(6):466-8. View

Fromtling R, Bulmer G . In vitro effect of aqueous extract of garlic (Allium sativum) on the growth and viability of Cryptococcus neoformans. Mycologia. 1978; 70(2):397-405. View

Dankert J, Tromp T, de Vries H, Klasen H . Antimicrobial activity of crude juices of Allium ascalonicum, Allium cepa and Allium sativum. Zentralbl Bakteriol Orig A. 1979; 245(1-2):229-39. View