Endogenous Pyrogen Activity in Human Plasma After Exercise

Overview

Journal Science

Specialty Science

Date 1983 May 6

PMID 6836306

Citations 52

Authors

J G Cannon

M J Kluger

Affiliations

Soon will be listed here.

Abstract

Plasma obtained from human subjects after exercise and injected intraperitoneally into rats elevated rat rectal temperature and depressed plasma iron and zinc concentrations. The pyrogenic component was heat-denaturable and had an apparent molecular weight of 14,000 daltons. Human mononuclear leukocytes obtained after exercise and incubated in vitro released a factor into the medium that also elevated body temperature in rats and reduced trace metal concentrations. These results suggest that endogenous pyrogen, a protein mediator of fever and trace metal metabolism during infection, is released during exercise.

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