Stereospecific Enhancement of Evoked Release of Brain Acetylcholine by Narcotic Antagonists

Overview

Journal Br J Pharmacol

Publisher Wiley

Specialty Pharmacology

Date 1983 Feb 1

PMID 6831119

Citations 2

Authors

K Jhamandas

M Sutak

Affiliations

Soon will be listed here.

Abstract

1--Electrical stimulation of nerves in the forepaw of anaesthetized rats caused an increase in the release of acetylcholine (ACh) from the cerebral cortex in vivo. Actions of naloxone (Nal) enantiomers and naltrexone (Ntx) were tested on this release in normal animals and those lacking pituitary gland for 3 weeks. 2--In normal animals systemic administration of (-)-Nal or Ntx, but not (+)-Nal caused a significant increase in the evoked release of ACh. Spinally administered (-)-Nal did not produce this effect. Cortical application of (-)-Nal produced a smaller increase in the evoked release of ACh. 3--In hypophysectomized rats the stimulatory action of (-)-Nal or Ntx on ACh release was significantly reduced. The ability of (-)-Nal to reverse inhibitory action of morphine or the enkephalin (FK 33,824) was not affected by hypophysectomy. 4--It is suggested that (-)-Nal and Ntx increase the stimulated release of cortical ACh by blocking the inhibitory action of an endogenous opioid at a subcortical site. An intact pituitary appears essential for a full expression of the Nal effect on evoked ACh release.

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References

Waterfield A, KOSTERLITZ H . Stereospecific increase by narcotic antagonists of evoked acetylcholine output in guinea-pig ileum. Life Sci. 1975; 16(12):1787-92. DOI: 10.1016/0024-3205(75)90275-1. View

Jhamandas K, Hron V, Sutak M . Comparative effects of opiate agonists methadone, levorphanol, and their isomers on the release of cortical ACh in vivo and in vitro. Can J Physiol Pharmacol. 1975; 53(4):540-8. DOI: 10.1139/y75-076. View

Hughes J, Smith T, KOSTERLITZ H, Fothergill L, Morgan B, Morris H . Identification of two related pentapeptides from the brain with potent opiate agonist activity. Nature. 1975; 258(5536):577-80. DOI: 10.1038/258577a0. View

Terenius L . Somatostatin and ACTH are peptides with partial antagonist-like selectivity for opiate receptors. Eur J Pharmacol. 1976; 38(1):211-3. DOI: 10.1016/0014-2999(76)90221-1. View

Jhamandas K, Sutak M . Morphine-naloxone interaction in the central cholinergic system: the influence of subcortical lesioning and electrical stimulation. Br J Pharmacol. 1976; 58(1):101-7. PMC: 1667128. DOI: 10.1111/j.1476-5381.1976.tb07697.x. View

Moroni F, Cheney D, Costa E . beta endorphin inhibits ACh turnover in nuclei of rat brain. Nature. 1977; 267(5608):267-8. DOI: 10.1038/267267a0. View

Yaksh T, Rudy T . Studies on the direct spinal action of narcotics in the production of analgesia in the rat. J Pharmacol Exp Ther. 1977; 202(2):411-28. View

Jhamandas K, Sawynok J, Sutak M . Enkephalin effects on release of brain acetylcholine. Nature. 1977; 269(5627):433-4. DOI: 10.1038/269433a0. View

Frederickson R, Burgis V, Edwards J . Hyperalgesia induced by naloxone follows diurnal rhythm in responsivity to painful stimuli. Science. 1977; 198(4318):756-8. DOI: 10.1126/science.561998. View

10.

Rossier J, Vargo T, Minick S, Ling N, Bloom F, Guillemin R . Regional dissociation of beta-endorphin and enkephalin contents in rat brain and pituitary. Proc Natl Acad Sci U S A. 1977; 74(11):5162-5. PMC: 432121. DOI: 10.1073/pnas.74.11.5162. View

11.

Cuello A, Paxinos G . Evidence for a long Leu-enkephalin striopallidal pathway in rat brain. Nature. 1978; 271(5641):178-80. DOI: 10.1038/271178a0. View

12.

Kobayashi R, Palkovits M, Miller R, Chang K, Cuatrecasas P . Brain enkephalin distribution is unaltered by hypophysectomy. Life Sci. 1978; 22(6):527-30. DOI: 10.1016/0024-3205(78)90434-4. View

13.

Wood P, Cheney D, Costa E . Modulation of the turnover rate of acetylcholine in rat brain by intraventricular injections of thyrotropin-releasing hormone, somatostatin, neurotensin and angiotensin II. J Neurochem. 1978; 31(3):685-91. DOI: 10.1111/j.1471-4159.1978.tb07841.x. View

14.

Grevert P, Baizman E, Goldstein A . Naloxone effects on a nociceptive response of hypophysectomized and adrenalectomized mice. Life Sci. 1978; 23(7):723-8. DOI: 10.1016/0024-3205(78)90072-3. View

15.

Johnston M, McKinney M, Coyle J . Evidence for a cholinergic projection to neocortex from neurons in basal forebrain. Proc Natl Acad Sci U S A. 1979; 76(10):5392-6. PMC: 413149. DOI: 10.1073/pnas.76.10.5392. View

16.

ODonohue T, Holmquist G, Jacobowitz D . Effect of hypophysectomy on alpha-melanotropin in discrete regions of the rat brain. Neurosci Lett. 1979; 14(2-3):271-4. DOI: 10.1016/0304-3940(79)96160-3. View

17.

Lehmann J, Nagy J, Atmadia S, Fibiger H . The nucleus basalis magnocellularis: the origin of a cholinergic projection to the neocortex of the rat. Neuroscience. 1980; 5(7):1161-74. DOI: 10.1016/0306-4522(80)90195-5. View

18.

Terry L, Crowley W . The effect of hypophysectomy on somatostatin-like immunoreactivity in discrete hypothalamic and extrahypothalamic nuclei. Endocrinology. 1980; 107(6):1771-5. DOI: 10.1210/endo-107-6-1771. View

19.

Henry J . Naloxone excites nociceptive units in the lumbar dorsal horn of the spinal cat. Neuroscience. 1979; 4(10):1485-91. DOI: 10.1016/0306-4522(79)90053-8. View

20.

Gibson A, GINSBURG M, Hart S, Kitchen I . Effects of adrenalectomy and hypophysectomy on enkephalin content of the rat hypothalamus. Br J Pharmacol. 1980; 70(4):561-9. PMC: 2044378. DOI: 10.1111/j.1476-5381.1980.tb09775.x. View