» Articles » PMID: 6825977

Free and Lipid Inositol, Sorbitol and Sugars in Sciatic Nerve Obtained Post-mortem from Diabetic Patients and Control Subjects

Overview
Journal Diabetologia
Specialty Endocrinology
Date 1983 Jan 1
PMID 6825977
Citations 22
Authors
Affiliations
Soon will be listed here.
Abstract

Sciatic nerves removed post-mortem from diabetic patients and normal subjects were analysed by gas chromatography for glucose, fructose, sorbitol and myo-inositol. The concentrations of free and lipid inositol were significantly lower in nerves from the diabetic than from the control group. Concentrations of glucose, fructose and sorbitol were higher in the nerves of the diabetic patients.

Citing Articles

Advanced glycation end-products: modifiable environmental factors profoundly mediate insulin resistance.

Ottum M, Mistry A J Clin Biochem Nutr. 2015; 57(1):1-12.

PMID: 26236094 PMC: 4512899. DOI: 10.3164/jcbn.15-3.


Influence of the polyol pathway on norepinephrine transporter reduction in diabetic cardiac sympathetic nerves: implications for heterogeneous accumulation of MIBG.

Kiyono Y, Kajiyama S, Fujiwara H, Kanegawa N, Saji H Eur J Nucl Med Mol Imaging. 2005; 32(8):993-7.

PMID: 16261676 DOI: 10.1007/s00259-005-1865-1.


Influence of the polyol pathway on norepinephrine transporter reduction in diabetic cardiac sympathetic nerves: implications for heterogeneous accumulation of MIBG.

Kiyono Y, Kajiyama S, Fujiwara H, Kanegawa N, Saji H Eur J Nucl Med Mol Imaging. 2005; 32(4):438-42.

PMID: 15821963 DOI: 10.1007/s00259-004-1694-7.


Osmotically-induced nerve taurine depletion and the compatible osmolyte hypothesis in experimental diabetic neuropathy in the rat.

Stevens M, Lattimer S, Kamijo M, Van Huysen C, Sima A, Greene D Diabetologia. 1993; 36(7):608-14.

PMID: 8359577 DOI: 10.1007/BF00404069.


The linked roles of nitric oxide, aldose reductase and, (Na+,K+)-ATPase in the slowing of nerve conduction in the streptozotocin diabetic rat.

Stevens M, Dananberg J, Feldman E, Lattimer S, Kamijo M, Thomas T J Clin Invest. 1994; 94(2):853-9.

PMID: 8040341 PMC: 296167. DOI: 10.1172/JCI117406.


References
1.
Brown M, Iwamori M, Kishimoto Y, Rapoport B, Moser H, Asbury A . Nerve lipid abnormalities in human diabetic neuropathy: a correlative study. Ann Neurol. 1979; 5(3):245-52. DOI: 10.1002/ana.410050306. View

2.
Stewart M, Sherman W, Kurien M, Moonsammy G, Wisgerhof M . Polyol accumulations in nervous tissue of rats with experimental diabetes and galactosaemia. J Neurochem. 1967; 14(11):1057-66. DOI: 10.1111/j.1471-4159.1967.tb09516.x. View

3.
Dyck P, Sherman W, Hallcher L, Service F, OBrien P, Grina L . Human diabetic endoneurial sorbitol, fructose, and myo-inositol related to sural nerve morphometry. Ann Neurol. 1980; 8(6):590-6. DOI: 10.1002/ana.410080608. View

4.
Jakobsen J . Peripheral nerves in early experimental diabetes: expansion of the endoneurial space as a cause of increased water content. Diabetologia. 1978; 14(2):113-9. DOI: 10.1007/BF01263449. View

5.
Palmano K, Whiting P, HAWTHORNE J . Free and lipid myo-inositol in tissues from rats with acute and less severe streptozotocin-induced diabetes. Biochem J. 1977; 167(1):229-35. PMC: 1183640. DOI: 10.1042/bj1670229. View