Peripheral Nerve Concentrations of Glucose, Fructose, Sorbitol and Myoinositol in Diabetic and Non-diabetic Patients

Overview

Journal Diabetologia

Specialty Endocrinology

Date 1987 Jul 1

PMID 3666344

Citations 5

Authors

P J Hale

M Nattrass

S H Silverman

C Sennit

C M Perkins

A Uden

G Sundkvist

Affiliations

Soon will be listed here.

Abstract

Glucose, fructose, sorbitol and myoinositol concentrations were measured in biopsies of peripheral nerve obtained at above-knee or below-knee amputation. In diabetic patients nerve glucose (median [range]) (5.09 [1.62-12.82] vs 3.12 [1.81-4.01]) p less than 0.001, fructose (0.245 [0.060-1.280] vs 0.150 [0.053-0.385]) p less than 0.05, and sorbitol (0.028 [0.012-0.496] vs 0.016 [0.007-0.059] p less than 0.02, mumol/g wet weight) were significantly higher than in non-diabetic patients. No significant difference was found in myoinositol concentration (1.95 [1.00-3.55] vs 2.09 [1.27-5.40] mumol/g wet weight). Concentrations differed markedly from previously reported values in human nerve obtained at post-mortem.

Citing Articles

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