» Articles » PMID: 6787085

Immunoglobulin G Heavy Chain (Gm) Allotypes in Multiple Sclerosis

Overview
Journal J Clin Invest
Specialty General Medicine
Date 1981 Jun 1
PMID 6787085
Citations 16
Authors
Affiliations
Soon will be listed here.
Abstract

Serum samples from 70 Caucasian patients with multiple sclerosis were typed for nine Gm markers. Significant association was found with the Gm 1,17;21 phenotype, and the relative risk for individuals with this phenotype was calculated at 3.6. The data indicate that Caucasians positive for Gm 1,17;21 are almost four times more likely to develop multiple sclerosis than those without this phenotype.

Citing Articles

Epistatic effects of IGHG and FCGRIIB genes on the development of Alzheimer's disease in African Americans.

Pandey J, Nietert P, Namboodiri A, Bennett D, Barnes L Immunogenetics. 2024; 77(1):1.

PMID: 39489839 PMC: 11532319. DOI: 10.1007/s00251-024-01358-4.


Coming together at the hinges: Therapeutic prospects of IgG3.

Chu T, Patz Jr E, Ackerman M MAbs. 2021; 13(1):1882028.

PMID: 33602056 PMC: 7899677. DOI: 10.1080/19420862.2021.1882028.


The forgotten tale of immunoglobulin allotypes in cancer risk and treatment.

Pandey J, Li Z Exp Hematol Oncol. 2013; 2(1):6.

PMID: 23425356 PMC: 3598368. DOI: 10.1186/2162-3619-2-6.


Genetic variants in the immunoglobulin heavy chain locus are associated with the IgG index in multiple sclerosis.

Buck D, Albrecht E, Aslam M, Goris A, Hauenstein N, Jochim A Ann Neurol. 2012; 73(1):86-94.

PMID: 23225573 PMC: 3661208. DOI: 10.1002/ana.23749.


Susceptibility to multiple sclerosis and the immunoglobulin heavy chain variable region.

Wood N, Sawcer S, Holmans P, Clayton D, Robertson N, Compston D J Neurol. 1995; 242(10):677-82.

PMID: 8568530 DOI: 10.1007/BF00866919.


References
1.
WOOLF B . On estimating the relation between blood group and disease. Ann Hum Genet. 1955; 19(4):251-3. DOI: 10.1111/j.1469-1809.1955.tb01348.x. View

2.
BERMAN P, Patrick J . Linkage between the frequency of muscular weakness and loci that regulate immune responsiveness in murine experimental myasthenia gravis. J Exp Med. 1980; 152(3):507-20. PMC: 2185932. DOI: 10.1084/jem.152.3.507. View

3.
Norrby E, Link H, Olsson J, Panelius M, Salmi A, Vandvik B . Comparison of antibodies against different viruses in cerebrospinal fluid and serum samples from patients with multiple sclerosis. Infect Immun. 1974; 10(4):688-94. PMC: 423007. DOI: 10.1128/iai.10.4.688-694.1974. View

4.
Saito S, Naito S, Kawanami S, Kurowa Y . HLA studies on multiple sclerosis in Japan. Neurology. 1976; 26(6 PT 2):49. DOI: 10.1212/wnl.26.6_part_2.49. View

5.
DuPont B, Lisak R, Jersild C, Hansen J, Silberberg D, Whitsett C . HLA antigens in black American patients with multiple sclerosis. Transplant Proc. 1977; 9(1 Suppl 1):181-5. View