The Effect of Long-term Concurrent Administration of Chlorpromazine and Lithium on the Striatal and Frontal Cortical Dopamine Metabolism in Rats

Overview

Journal Psychopharmacology (Berl)

Specialty Pharmacology

Date 1981 Jan 1

PMID 6785796

Citations 1

Authors

L Eroglu

A Hizal

H KOYUNCUOGLU

Affiliations

Soon will be listed here.

Abstract

The effects of lithium and chlorpromazine chronically administered alone and together on the dopamine metabolism in the rat striatum and frontal cortex were investigated by measurement of the levels of dopamine (DA) and its main metabolite, homovanillic acid (HVA). Long-term chlorpromazine administration caused a significant increase in the striatal DA level and a decrease in that of HVA and HVA/DA ratio without any changes in those of the frontal cortex. The prolonged administration of lithium elevated the striatal levels of both HVA and DA, but no change in the frontal cortex was observed. The concurrent administration of chlorpromazine and lithium caused a significant increase in the frontal cortical DA level and a decrease in that of HVA and HVA/DA ratio. The striatal DA and HVA levels increased under the effect of the combined treatment, while the HVA/DA ratio remained unchanged.

Citing Articles

Lithium does not interact with haloperidol in the dopaminergic pathways of the rat brain.

Reches A, Jackson-Lewis V, Fahn S Psychopharmacology (Berl). 1984; 82(4):330-4.

PMID: 6427824 DOI: 10.1007/BF00427680.

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