Differential Regional Development of Tolerance to Increase in Dopamine Turnover Upon Repeated Neuroleptic Administration

Overview

Journal Eur J Pharmacol

Specialty Pharmacology

Date 1977 Dec 15

PMID 590344

Citations 27

Authors

B Scatton

Affiliations

Soon will be listed here.

Abstract

Repeated treatment with haloperidol and sulpiride induced tolerance to the increases in homovanillic and dihydroxyphenyl acetic acids in the striatum, nucleus accumbens, tuberculum olfactorium and frontal cortex of the rat. The threshold dose inducing this effect appeared to be lower in the striatum than in the limbic regions. Similar results were found in the frontal cortex by measuring dopamine utilization. Moreover, tolerance developed earlier in the striatum than in the limbic areas. The possible reasons are discussed for the differential development of tolerance in the various DA areas investigated.

Citing Articles

Noradrenergic versus dopaminergic modulation of impulsivity, attention and monitoring behaviour in rats performing the stop-signal task: possible relevance to ADHD.

Bari A, Robbins T Psychopharmacology (Berl). 2013; 230(1):89-111.

PMID: 23681165 PMC: 3824307. DOI: 10.1007/s00213-013-3141-6.

Functional consequences of iron overload in catecholaminergic interactions: the Youdim factor.

Archer T, Fredriksson A Neurochem Res. 2007; 32(10):1625-39.

PMID: 17694434 DOI: 10.1007/s11064-007-9358-1.

Dopamine and serotonin metabolism in response to chronic administration of fluvoxamine and haloperidol combined treatment.

Chertkow Y, Weinreb O, Youdim M, Silver H J Neural Transm (Vienna). 2007; 114(11):1443-54.

PMID: 17576515 DOI: 10.1007/s00702-007-0753-1.

Postnatal iron-induced motor behaviour alterations following chronic neuroleptic administration in mice.

Fredriksson A, Eriksson P, Archer T J Neural Transm (Vienna). 2005; 113(2):137-50.

PMID: 16082515 DOI: 10.1007/s00702-005-0307-3.

Differential expression of autoreceptors in the ascending dopamine systems of the human brain.

Meador-Woodruff J, Damask S, Watson Jr S Proc Natl Acad Sci U S A. 1994; 91(17):8297-301.

PMID: 7914704 PMC: 44593. DOI: 10.1073/pnas.91.17.8297.