Alpha 2.0
Login Register
» Articles » PMID: 6771212

IgA Paraprotein Inhibition of Human Neutrophil Chemotaxis. Reduced Activity Following Treatment with IgA-specific Protease from Neisseria Gonorrhoeae

Overview
Journal Inflammation
Specialties Allergy & Immunology
Pathology
Date 1980 Jun 1
PMID 6771212
Citations 3
Authors
D E Van Epps
A Plaut
G M BERNIER
R C Williams Jr
Affiliations
Soon will be listed here.
Abstract

Removal of the Fc region of human IgA m components by treatment with IgA-specific protease from Neisseria gonorrhoeae reduces the neutrophil chemotactic inhibitory activity associated with IgA M components. This observation, along with the failure of an IgA halfmer paraprotein to inhibit neutrophil chemotaxis, emphasizes the importance of the IgA Fc region in the inhibition of neutrophil chemotaxis by IgA M components.

Citing Articles

IgA1 proteases of Haemophilus influenzae: cloning and characterization in Escherichia coli K-12.

Bricker J, Mulks M, Plaut A, Moxon E, Wright A Proc Natl Acad Sci U S A. 1983; 80(9):2681-5.

PMID: 6341996 PMC: 393891. DOI: 10.1073/pnas.80.9.2681.

The meningococcus and mechanisms of pathogenicity.

DeVoe I Microbiol Rev. 1982; 46(2):162-90.

PMID: 6126800 PMC: 281537. DOI: 10.1128/mr.46.2.162-190.1982.

Defense mechanisms involving Fc-dependent functions of immunoglobulin A and their subversion by bacterial immunoglobulin A proteases.

Kilian M, Mestecky J, Russell M Microbiol Rev. 1988; 52(2):296-303.

PMID: 3045518 PMC: 373140. DOI: 10.1128/mr.52.2.296-303.1988.

References
1.
Lawrence D, Weigle W, Spiegelberg H . Immunoglobulins cytophilic for human lymphocytes, monocytes, and neutrophils. J Clin Invest. 1975; 55(2):368-76. PMC: 301755. DOI: 10.1172/JCI107940. View
2.
Plaut A . Microbial IgA proteases. N Engl J Med. 1978; 298(26):1459-63. DOI: 10.1056/NEJM197806292982608. View
3.
BERNIER G, Johnson C, Fanger M . Structural and biosynthetic studies of a human IgA half molecule. J Immunol. 1977; 119(4):1260-5. View
4.
Goldblum S, Van Epps D, REED W . Serum inhibitor of C5 fragment-mediated polymorphonuclear leukocyte chemotaxis associated with chronic hemodialysis. J Clin Invest. 1979; 64(1):255-64. PMC: 372112. DOI: 10.1172/JCI109446. View
5.
Mannik M . Binding of albumin to gamma-A-myeloma proteins and Waldenström macroglobulins by disulfide bonds. J Immunol. 1967; 99(5):899-906. View