Metabolism of 7,12-dimethylbenzanthracene (DMBA) by Mouse Skin Keratinocytes, Fibroblasts, and Carcinoma Cells in Culture

Overview

Journal Arch Toxicol

Specialty Toxicology

Date 1980 Mar 1

PMID 6770796

Authors

G IRMSCHER

N E Fusenig

Affiliations

Soon will be listed here.

References

DIPAOLO J, Donovan P, Nelson R . In vitro transformation of hamster cells by polycyclic hydrocarbons: factors influencing the number of cells transformed. Nat New Biol. 1971; 230(16):240-2. DOI: 10.1038/newbio230240a0. View

Gelboin H, Huberman E, Sachs L . Enzymatic hydroxylation of benzopyrene and its relationship to cytotoxicity. Proc Natl Acad Sci U S A. 1969; 64(4):1188-94. PMC: 223267. DOI: 10.1073/pnas.64.4.1188. View

Huberman E, Sachs L . Susceptibility of cells transformed by polyoma virus and simian virus 40 to the cytotoxic effect of the carcinogenic hydrocarbon benzo[a]pyrene. J Natl Cancer Inst. 1968; 40(2):329-36. View

Yuspa S, Hennings H, Dermer P, Michael D . Dimethyl sulfoxide-induced enhancement of 7,12-dimethylbenz(a)anthracene metabolism and DNA binding in differentiating mouse epidermal cell cultures. Cancer Res. 1976; 36(3):947-51. View

Marquardt H, Grover P, Sims P . In vitro malignant transformation of mouse fibroblasts by non-K-region dihydrodiols derived from 7-methylbenz(a)anthracene, 7,12-dimethylbenz(a)anthracene, and benzo(a)pyrene. Cancer Res. 1976; 36(6):2059-64. View

Huberman E, Chou M, Yang S . Identification of 7,12-dimethylbenz[a]anthracene metabolites that lead to mutagenesis in mammalian cells. Proc Natl Acad Sci U S A. 1979; 76(2):862-6. PMC: 383073. DOI: 10.1073/pnas.76.2.862. View

Akin F, Norred W . Factors affecting measurement of aryl hydrocarbon hydroxylase activity in mouse skin. J Invest Dermatol. 1976; 67(6):709-12. DOI: 10.1111/1523-1747.ep12598592. View

Thompson S, Slaga T . Mouse epidermal aryl hydrocarbon hydroxylase. J Invest Dermatol. 1976; 66(02):108-11. DOI: 10.1111/1523-1747.ep12481449. View

Slaga T, Gleason G, DiGiovanni J, Sukumaran K, Harvey R . Potent tumor-initiating activity of the 3,4-dihydrodiol of 7,12-dimethylbenz(a)anthracene in mouse skin. Cancer Res. 1979; 39(6 Pt 1):1934-6. View

10.

Brown A . In vitro transformation of submandibular gland epithelial cells and fibroblasts of adult rats by methylcholanthrene. Cancer Res. 1973; 33(11):2779-89. View

11.

Freeman A, Lake R, IGEL H, Gernand L, Pezzutti M, Malone J . Heteroploid conversion of human skin cells by methylcholanthrene. Proc Natl Acad Sci U S A. 1977; 74(6):2451-5. PMC: 432190. DOI: 10.1073/pnas.74.6.2451. View

12.

Sims P . The metabolism of some aromatic hydrocarbons by mouse embryo cell cultures. Biochem Pharmacol. 1970; 19(1):285-97. DOI: 10.1016/0006-2952(70)90348-5. View

13.

Autrup H, Harris C, Stoner G, Selkirk J, SCHAFER P, Trump B . Metabolism of [3H]benzo[a]pyrene by cultured human bronchus and cultured human pulmonary alveolar macrophages. Lab Invest. 1978; 38(3):217-24. View

14.

Harris C, Autrup H, Stoner G, Yang S, Leutz J, Gelboin H . Metabolism of benzo[a]pyrene and 7,12-dimethylbenz[a]anthracene in cultured human bronchus and pancreatic duct. Cancer Res. 1977; 37(9):3349-55. View

15.

Landolph J, Bartholomew J, Calvin M . Quantitative studies of the toxicity of benzo(a)pyrene to a mouse liver epithelial cell strain in culture. Cancer Res. 1976; 36(11 Pt 1):4143-51. View

16.

Diamond L, Defendi V, Brookes P . The development of resistance to carcinogen-induced cytotoxicity in hamster embryo cultures. Exp Cell Res. 1968; 52(1):180-4. DOI: 10.1016/0014-4827(68)90557-0. View

17.

Vasiliev J, Guelstein V . SENSITIVITY OF NORMAL AND NEOPLASTIC CELLS TO THE DAMAGING ACTION OF CARCINOGENIC SUBSTANCES: A REVIEW. J Natl Cancer Inst. 1963; 31:1123-51. View

18.

Williams G, Elliott J, WEISBURGER J . Carcinoma after malignant conversion in vitro of epithelial-like cells from rat liver following exposure to chemical carcinogens. Cancer Res. 1973; 33(3):606-12. View

19.

Dipple A, Tomaszewski J, Moschel R, Bigger C, Nebzydoski J, Egan M . Comparison of metabolism-mediated binding to DNA of 7-hydroxymethyl-12-methylbenz(a)anthracene and 7, 12-dimethylbenz(a)anthracene. Cancer Res. 1979; 39(4):1154-8. View

20.

Landolph J, Becker J, Gamper H, Bartholomew J, Calvin M . Biochemical basis for the acquisition of resistance to benzo[a]pyrene in clones of mouse liver cells in culture. Chem Biol Interact. 1978; 23(3):331-44. DOI: 10.1016/0009-2797(78)90094-7. View