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Organization and Complete Sequence of Identical Embryonic and Plasmacytoma Kappa V-region Genes

Overview
Journal J Biol Chem
Specialty Biochemistry
Date 1980 Apr 25
PMID 6767723
Citations 68
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Abstract

We have determined the entire sequence of two immunoglobulin kappa variable region genes derived separately from embryonic and plasmacytoma cells. Both genes are in the germline configuration; both are organized into hydrophobic leader and mature V-region coding sequences separated by a short intervening sequence. Both are identical with one another throughout the 1360 bases determined. In addition, there is a simple repeat sequence of 31 CA doublets that occurs about 300 bases from the 3' side of the coding sequence in each gene.

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